STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Adam3aADAM metallopeptidase domain 3A. (769 aa)    
Predicted Functional Partners:
Zpbp2
Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization; Belongs to the zona pellucida-binding protein Sp38 family.
   
  
 0.874
Pdilt
Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis.
   
 
 0.849
Zp3r
Zona pellucida sperm-binding protein 3 receptor; Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction (By similarity).
   
  
 0.846
Cd46
Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
   
  
 0.814
Man2b2
Alpha-mannosidase.
      
 0.775
Clgn
Calmegin.
   
 
 0.728
Prss37
Similar to RIKEN cDNA 1700016G05 (Predicted).
   
  
 0.721
Adam4
A disintegrin and metalloprotease domain 4.
  
   
0.686
Calr3
Calreticulin.
    
 
 0.668
Izumo1
Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
      
 0.668
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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