node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aasdh | Cyp20a1 | ENSRNOP00000002907 | ENSRNOP00000023796 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | 0.511 |
Aasdh | Cyp26b1 | ENSRNOP00000002907 | ENSRNOP00000020505 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] | 0.511 |
Aasdh | Cyp2j10 | ENSRNOP00000002907 | ENSRNOP00000054968 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 2J3; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9- epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA). | 0.485 |
Aasdh | Cyp39a1 | ENSRNOP00000002907 | ENSRNOP00000014051 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450, family 39, subfamily a, polypeptide 1 (Predicted), isoform CRA_a; Belongs to the cytochrome P450 family. | 0.474 |
Aasdh | Cyp7a1 | ENSRNOP00000002907 | ENSRNOP00000012819 | Aminoadipate-semialdehyde dehydrogenase. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting st [...] | 0.615 |
Aasdh | Cyp7b1 | ENSRNOP00000002907 | ENSRNOP00000013116 | Aminoadipate-semialdehyde dehydrogenase. | 25-hydroxycholesterol 7-alpha-hydroxylase; Oxysterol 7alpha-hydroxylase that mediates formation of 7- alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. | 0.578 |
Aasdh | Hsd3b7 | ENSRNOP00000002907 | ENSRNOP00000025933 | Aminoadipate-semialdehyde dehydrogenase. | 3 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymph [...] | 0.460 |
Akr1e2 | Cyp20a1 | ENSRNOP00000023133 | ENSRNOP00000023796 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol. | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | 0.544 |
Akr1e2 | Cyp39a1 | ENSRNOP00000023133 | ENSRNOP00000014051 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol. | Cytochrome P450, family 39, subfamily a, polypeptide 1 (Predicted), isoform CRA_a; Belongs to the cytochrome P450 family. | 0.415 |
Cyp20a1 | Aasdh | ENSRNOP00000023796 | ENSRNOP00000002907 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Aminoadipate-semialdehyde dehydrogenase. | 0.511 |
Cyp20a1 | Akr1e2 | ENSRNOP00000023796 | ENSRNOP00000023133 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol. | 0.544 |
Cyp20a1 | Cyp26b1 | ENSRNOP00000023796 | ENSRNOP00000020505 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] | 0.579 |
Cyp20a1 | Cyp2j10 | ENSRNOP00000023796 | ENSRNOP00000054968 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Cytochrome P450 2J3; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9- epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA). | 0.510 |
Cyp20a1 | Cyp39a1 | ENSRNOP00000023796 | ENSRNOP00000014051 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 39, subfamily a, polypeptide 1 (Predicted), isoform CRA_a; Belongs to the cytochrome P450 family. | 0.726 |
Cyp20a1 | Cyp7a1 | ENSRNOP00000023796 | ENSRNOP00000012819 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting st [...] | 0.633 |
Cyp20a1 | Cyp7b1 | ENSRNOP00000023796 | ENSRNOP00000013116 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | 25-hydroxycholesterol 7-alpha-hydroxylase; Oxysterol 7alpha-hydroxylase that mediates formation of 7- alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. | 0.517 |
Cyp20a1 | Hsd3b7 | ENSRNOP00000023796 | ENSRNOP00000025933 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | 3 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymph [...] | 0.558 |
Cyp20a1 | Nol9 | ENSRNOP00000023796 | ENSRNOP00000013535 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Nucleolar protein 9. | 0.547 |
Cyp20a1 | Slc35e2b | ENSRNOP00000023796 | ENSRNOP00000023097 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. | Solute carrier family 35, member E2 (Predicted). | 0.507 |
Cyp26b1 | Aasdh | ENSRNOP00000020505 | ENSRNOP00000002907 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] | Aminoadipate-semialdehyde dehydrogenase. | 0.511 |