STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Doc2gDouble C2-like domain-containing protein. (387 aa)    
Predicted Functional Partners:
Tas2r134
Taste receptor type 2 member 134; Putative taste receptor which may play a role in the perception of bitterness; Belongs to the G-protein coupled receptor T2R family.
   
  
 0.583
S100a5
Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.
   
  
 0.572
Oacyl
RCG46764, isoform CRA_b.
      
 0.525
Rwdd2a
RWD domain-containing protein.
   
  
 0.524
Fam89a
Protein FAM89A; Belongs to the FAM89 family.
      
 0.486
Gng4
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
      
 0.480
Cdhr1
Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
      
 0.463
Fuz
Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity); Belongs to the fuzzy family.
      
 0.410
Cd300lg
Cd300 molecule-like family member G.
      
 0.406
Adam5
Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity).
   
  
 0.405
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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