node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crk | Crkl | ENSRNOP00000006407 | ENSRNOP00000002552 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | 0.956 |
Crk | Egfr | ENSRNOP00000006407 | ENSRNOP00000006087 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Receptor protein-tyrosine kinase. | 0.988 |
Crk | Gab1 | ENSRNOP00000006407 | ENSRNOP00000071006 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | GRB2-associated-binding protein 1. | 0.983 |
Crk | Grb2 | ENSRNOP00000006407 | ENSRNOP00000005347 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.906 |
Crk | Met | ENSRNOP00000006407 | ENSRNOP00000070486 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.851 |
Crk | Pik3r1 | ENSRNOP00000006407 | ENSRNOP00000025687 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.922 |
Crk | Ptpn11 | ENSRNOP00000006407 | ENSRNOP00000041842 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.487 |
Crk | Shc1 | ENSRNOP00000006407 | ENSRNOP00000028038 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). | 0.827 |
Crk | Sos1 | ENSRNOP00000006407 | ENSRNOP00000009359 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.809 |
Crk | Sos2 | ENSRNOP00000006407 | ENSRNOP00000006425 | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | SOS Ras/Rho guanine nucleotide exchange factor 2. | 0.668 |
Crkl | Crk | ENSRNOP00000002552 | ENSRNOP00000006407 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | 0.956 |
Crkl | Egfr | ENSRNOP00000002552 | ENSRNOP00000006087 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | Receptor protein-tyrosine kinase. | 0.982 |
Crkl | Gab1 | ENSRNOP00000002552 | ENSRNOP00000071006 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | GRB2-associated-binding protein 1. | 0.984 |
Crkl | Grb2 | ENSRNOP00000002552 | ENSRNOP00000005347 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. | 0.888 |
Crkl | Met | ENSRNOP00000002552 | ENSRNOP00000070486 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.829 |
Crkl | Pik3r1 | ENSRNOP00000002552 | ENSRNOP00000025687 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.886 |
Crkl | Ptpn11 | ENSRNOP00000002552 | ENSRNOP00000041842 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.703 |
Crkl | Shc1 | ENSRNOP00000002552 | ENSRNOP00000028038 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). | 0.846 |
Crkl | Sos1 | ENSRNOP00000002552 | ENSRNOP00000009359 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.787 |
Crkl | Sos2 | ENSRNOP00000002552 | ENSRNOP00000006425 | Crk-like protein; May mediate the transduction of intracellular signals. Belongs to the CRK family. | SOS Ras/Rho guanine nucleotide exchange factor 2. | 0.779 |