node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Camta2 | Pitpnm1 | ENSRNOP00000053461 | ENSRNOP00000025084 | Calmodulin-binding transcription activator 2. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.658 |
Cdipt | Pitpnm1 | ENSRNOP00000013691 | ENSRNOP00000025084 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.614 |
Esyt1 | Esyt2 | ENSRNOP00000070299 | ENSRNOP00000006582 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Extended synaptotagmin 2. | 0.919 |
Esyt1 | Esyt3 | ENSRNOP00000070299 | ENSRNOP00000017658 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Extended synaptotagmin 3. | 0.853 |
Esyt1 | Osbp | ENSRNOP00000070299 | ENSRNOP00000061365 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.702 |
Esyt1 | Pitpnm1 | ENSRNOP00000070299 | ENSRNOP00000025084 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.685 |
Esyt1 | Vapa | ENSRNOP00000070299 | ENSRNOP00000074577 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking. | 0.529 |
Esyt1 | Vapb | ENSRNOP00000070299 | ENSRNOP00000007554 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.489 |
Esyt2 | Esyt1 | ENSRNOP00000006582 | ENSRNOP00000070299 | Extended synaptotagmin 2. | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | 0.919 |
Esyt2 | Esyt3 | ENSRNOP00000006582 | ENSRNOP00000017658 | Extended synaptotagmin 2. | Extended synaptotagmin 3. | 0.847 |
Esyt2 | Osbp | ENSRNOP00000006582 | ENSRNOP00000061365 | Extended synaptotagmin 2. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.534 |
Esyt2 | Pitpnm1 | ENSRNOP00000006582 | ENSRNOP00000025084 | Extended synaptotagmin 2. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.642 |
Esyt3 | Esyt1 | ENSRNOP00000017658 | ENSRNOP00000070299 | Extended synaptotagmin 3. | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | 0.853 |
Esyt3 | Esyt2 | ENSRNOP00000017658 | ENSRNOP00000006582 | Extended synaptotagmin 3. | Extended synaptotagmin 2. | 0.847 |
Esyt3 | Osbp | ENSRNOP00000017658 | ENSRNOP00000061365 | Extended synaptotagmin 3. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.482 |
Esyt3 | Pitpnm1 | ENSRNOP00000017658 | ENSRNOP00000025084 | Extended synaptotagmin 3. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.634 |
Esyt3 | Vapa | ENSRNOP00000017658 | ENSRNOP00000074577 | Extended synaptotagmin 3. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking. | 0.466 |
Osbp | Esyt1 | ENSRNOP00000061365 | ENSRNOP00000070299 | Oxysterol-binding protein; Belongs to the OSBP family. | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | 0.702 |
Osbp | Esyt2 | ENSRNOP00000061365 | ENSRNOP00000006582 | Oxysterol-binding protein; Belongs to the OSBP family. | Extended synaptotagmin 2. | 0.534 |
Osbp | Esyt3 | ENSRNOP00000061365 | ENSRNOP00000017658 | Oxysterol-binding protein; Belongs to the OSBP family. | Extended synaptotagmin 3. | 0.482 |