node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cul1 | Fbxw2 | ENSRNOP00000007620 | ENSRNOP00000025399 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.899 |
Cul1 | Fbxw4 | ENSRNOP00000007620 | ENSRNOP00000067326 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box and WD-40 domain protein 4 (Predicted). | 0.777 |
Cul1 | Fbxw5 | ENSRNOP00000007620 | ENSRNOP00000029229 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | 0.873 |
Cul1 | Fbxw9 | ENSRNOP00000007620 | ENSRNOP00000005581 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box and WD repeat domain-containing 9. | 0.802 |
Cul1 | Nedd8 | ENSRNOP00000007620 | ENSRNOP00000061284 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.998 |
Cul1 | Psmd5 | ENSRNOP00000007620 | ENSRNOP00000025433 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 5 (Predicted), isoform CRA_a. | 0.533 |
Cul1 | Rbx1 | ENSRNOP00000007620 | ENSRNOP00000069049 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul1 | Skp1 | ENSRNOP00000007620 | ENSRNOP00000073214 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Fbxw2 | Cul1 | ENSRNOP00000025399 | ENSRNOP00000007620 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.899 |
Fbxw2 | Fbxw4 | ENSRNOP00000025399 | ENSRNOP00000067326 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box and WD-40 domain protein 4 (Predicted). | 0.688 |
Fbxw2 | Fbxw5 | ENSRNOP00000025399 | ENSRNOP00000029229 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | 0.643 |
Fbxw2 | Fbxw9 | ENSRNOP00000025399 | ENSRNOP00000005581 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box and WD repeat domain-containing 9. | 0.605 |
Fbxw2 | Nedd8 | ENSRNOP00000025399 | ENSRNOP00000061284 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.610 |
Fbxw2 | Pak1ip1 | ENSRNOP00000025399 | ENSRNOP00000033583 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | PAK1-interacting protein 1. | 0.664 |
Fbxw2 | Psmd5 | ENSRNOP00000025399 | ENSRNOP00000025433 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 5 (Predicted), isoform CRA_a. | 0.618 |
Fbxw2 | Rbx1 | ENSRNOP00000025399 | ENSRNOP00000069049 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Ring-box 1. | 0.714 |
Fbxw2 | Skp1 | ENSRNOP00000025399 | ENSRNOP00000073214 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.898 |
Fbxw2 | Zfp414 | ENSRNOP00000025399 | ENSRNOP00000011094 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.624 |
Fbxw4 | Cul1 | ENSRNOP00000067326 | ENSRNOP00000007620 | F-box and WD-40 domain protein 4 (Predicted). | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.777 |
Fbxw4 | Fbxw2 | ENSRNOP00000067326 | ENSRNOP00000025399 | F-box and WD-40 domain protein 4 (Predicted). | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.688 |