node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atoh1 | Barhl1 | ENSRNOP00000008358 | ENSRNOP00000017725 | Atonal bHLH transcription factor 1. | BarH-like 1 homeobox protein. | 0.702 |
Atoh1 | Espn | ENSRNOP00000008358 | ENSRNOP00000039445 | Atonal bHLH transcription factor 1. | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | 0.525 |
Atoh1 | Gfi1 | ENSRNOP00000008358 | ENSRNOP00000002807 | Atonal bHLH transcription factor 1. | Zinc finger protein Gfi-1; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. [...] | 0.720 |
Atoh1 | Myo6 | ENSRNOP00000008358 | ENSRNOP00000016428 | Atonal bHLH transcription factor 1. | Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.500 |
Atoh1 | Myo7a | ENSRNOP00000008358 | ENSRNOP00000019053 | Atonal bHLH transcription factor 1. | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.750 |
Atoh1 | Ocm2 | ENSRNOP00000008358 | ENSRNOP00000040755 | Atonal bHLH transcription factor 1. | Oncomodulin; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions; Belongs to the parvalbumin family. | 0.499 |
Atoh1 | Pou4f3 | ENSRNOP00000008358 | ENSRNOP00000025465 | Atonal bHLH transcription factor 1. | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear. | 0.780 |
Atoh1 | Slc26a5 | ENSRNOP00000008358 | ENSRNOP00000015733 | Atonal bHLH transcription factor 1. | Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasm [...] | 0.501 |
Atoh1 | Tmc1 | ENSRNOP00000008358 | ENSRNOP00000075695 | Atonal bHLH transcription factor 1. | Transmembrane channel-like protein. | 0.514 |
Atoh7 | Pou4f3 | ENSRNOP00000000432 | ENSRNOP00000025465 | Atonal bHLH transcription factor 7. | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear. | 0.539 |
Barhl1 | Atoh1 | ENSRNOP00000017725 | ENSRNOP00000008358 | BarH-like 1 homeobox protein. | Atonal bHLH transcription factor 1. | 0.702 |
Barhl1 | Pou4f3 | ENSRNOP00000017725 | ENSRNOP00000025465 | BarH-like 1 homeobox protein. | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear. | 0.563 |
Espn | Atoh1 | ENSRNOP00000039445 | ENSRNOP00000008358 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Atonal bHLH transcription factor 1. | 0.525 |
Espn | Myo6 | ENSRNOP00000039445 | ENSRNOP00000016428 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.883 |
Espn | Myo7a | ENSRNOP00000039445 | ENSRNOP00000019053 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.757 |
Espn | Pou4f3 | ENSRNOP00000039445 | ENSRNOP00000025465 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear. | 0.575 |
Espn | Slc26a5 | ENSRNOP00000039445 | ENSRNOP00000015733 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasm [...] | 0.653 |
Espn | Tmc1 | ENSRNOP00000039445 | ENSRNOP00000075695 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] | Transmembrane channel-like protein. | 0.636 |
Gfi1 | Atoh1 | ENSRNOP00000002807 | ENSRNOP00000008358 | Zinc finger protein Gfi-1; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. [...] | Atonal bHLH transcription factor 1. | 0.720 |
Gfi1 | Myo7a | ENSRNOP00000002807 | ENSRNOP00000019053 | Zinc finger protein Gfi-1; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. [...] | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.467 |