node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fancg | Fancm | ENSRNOP00000069926 | ENSRNOP00000074177 | FA complementation group G. | FA complementation group M. | 0.999 |
Fancg | Nutf2 | ENSRNOP00000069926 | ENSRNOP00000025608 | FA complementation group G. | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. | 0.819 |
Fancm | Fancg | ENSRNOP00000074177 | ENSRNOP00000069926 | FA complementation group M. | FA complementation group G. | 0.999 |
Fancm | Nutf2 | ENSRNOP00000074177 | ENSRNOP00000025608 | FA complementation group M. | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. | 0.823 |
Nup153 | Nup54 | ENSRNOP00000001979 | ENSRNOP00000003070 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.984 |
Nup153 | Nup58 | ENSRNOP00000001979 | ENSRNOP00000017204 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.933 |
Nup153 | Nup62 | ENSRNOP00000001979 | ENSRNOP00000067556 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity). It might be involved in protein recruitment to the centrosome after nuc [...] | 0.976 |
Nup153 | Nutf2 | ENSRNOP00000001979 | ENSRNOP00000025608 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. | 0.797 |
Nup153 | Nxt1 | ENSRNOP00000001979 | ENSRNOP00000006205 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | NTF2-related export protein 1 (Predicted), isoform CRA_a. | 0.740 |
Nup153 | Ran | ENSRNOP00000001979 | ENSRNOP00000001247 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] | 0.967 |
Nup153 | Ranbp1 | ENSRNOP00000001979 | ENSRNOP00000002579 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | RAN-binding protein 1. | 0.776 |
Nup153 | Rcc1 | ENSRNOP00000001979 | ENSRNOP00000074333 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | Regulator of chromosome condensation 1. | 0.639 |
Nup54 | Nup153 | ENSRNOP00000003070 | ENSRNOP00000001979 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC [...] | 0.984 |
Nup54 | Nup58 | ENSRNOP00000003070 | ENSRNOP00000017204 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | 0.999 |
Nup54 | Nup62 | ENSRNOP00000003070 | ENSRNOP00000067556 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity). It might be involved in protein recruitment to the centrosome after nuc [...] | 0.999 |
Nup54 | Nutf2 | ENSRNOP00000003070 | ENSRNOP00000025608 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. | 0.878 |
Nup54 | Nxt1 | ENSRNOP00000003070 | ENSRNOP00000006205 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | NTF2-related export protein 1 (Predicted), isoform CRA_a. | 0.629 |
Nup54 | Ran | ENSRNOP00000003070 | ENSRNOP00000001247 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] | 0.624 |
Nup54 | Ranbp1 | ENSRNOP00000003070 | ENSRNOP00000002579 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | RAN-binding protein 1. | 0.886 |
Nup54 | Rcc1 | ENSRNOP00000003070 | ENSRNOP00000074333 | Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | Regulator of chromosome condensation 1. | 0.489 |