STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Epdr1Mammalian ependymin-related protein 1; Ependymin related 1 (224 aa)    
Predicted Functional Partners:
Hecw1
Similar to HECT type E3 ubiquitin ligase (Predicted), isoform CRA_b; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
   
  
 0.683
Stard3nl
STARD3 N-terminal like, isoform CRA_a; STARD3 N-terminal like
   
  
 0.683
ENSRNOG00000039306
Uncharacterized protein
      
 0.676
Tox4
TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase
      
 0.660
Pus7
Pseudouridylate synthase 7
      
 0.636
Chd8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsiv [...]
      
 0.624
Ccdc71
Coiled-coil domain containing 71
      
 0.608
Amz1
Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2 (By similarity)
      
 0.607
Phf14
Similar to PHD finger protein 14 isoform 1 (Predicted), isoform CRA_b; PHD finger protein 14
      
 0.580
Snrpgl2
Small nuclear ribonucleoprotein G-like
      
 0.550
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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