node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bub1 | Bub1b | ENSRNOP00000042114 | ENSRNOP00000010406 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.996 |
Bub1 | Cdc20 | ENSRNOP00000042114 | ENSRNOP00000037772 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
Bub1 | Cdca8 | ENSRNOP00000042114 | ENSRNOP00000043633 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | 0.942 |
Bub1 | Cenpa | ENSRNOP00000042114 | ENSRNOP00000012512 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Similar to centromere protein A (Predicted), isoform CRA_b. | 0.933 |
Bub1 | Cenpe | ENSRNOP00000042114 | ENSRNOP00000032795 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.976 |
Bub1 | Cenpf | ENSRNOP00000042114 | ENSRNOP00000004525 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Centromere protein F. | 0.967 |
Bub1 | Kif18b | ENSRNOP00000042114 | ENSRNOP00000034491 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). | 0.809 |
Bub1 | Kif20a | ENSRNOP00000042114 | ENSRNOP00000037441 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.933 |
Bub1 | Kif2c | ENSRNOP00000042114 | ENSRNOP00000025903 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment. | 0.966 |
Bub1 | Plk1 | ENSRNOP00000042114 | ENSRNOP00000025629 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.980 |
Bub1b | Bub1 | ENSRNOP00000010406 | ENSRNOP00000042114 | BUB1 mitotic checkpoint serine/threonine kinase B. | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | 0.996 |
Bub1b | Cdc20 | ENSRNOP00000010406 | ENSRNOP00000037772 | BUB1 mitotic checkpoint serine/threonine kinase B. | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
Bub1b | Cdca8 | ENSRNOP00000010406 | ENSRNOP00000043633 | BUB1 mitotic checkpoint serine/threonine kinase B. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | 0.952 |
Bub1b | Cenpa | ENSRNOP00000010406 | ENSRNOP00000012512 | BUB1 mitotic checkpoint serine/threonine kinase B. | Similar to centromere protein A (Predicted), isoform CRA_b. | 0.916 |
Bub1b | Cenpe | ENSRNOP00000010406 | ENSRNOP00000032795 | BUB1 mitotic checkpoint serine/threonine kinase B. | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.996 |
Bub1b | Cenpf | ENSRNOP00000010406 | ENSRNOP00000004525 | BUB1 mitotic checkpoint serine/threonine kinase B. | Centromere protein F. | 0.992 |
Bub1b | Kif18b | ENSRNOP00000010406 | ENSRNOP00000034491 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). | 0.859 |
Bub1b | Kif20a | ENSRNOP00000010406 | ENSRNOP00000037441 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.936 |
Bub1b | Kif2c | ENSRNOP00000010406 | ENSRNOP00000025903 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment. | 0.953 |
Bub1b | Plk1 | ENSRNOP00000010406 | ENSRNOP00000025629 | BUB1 mitotic checkpoint serine/threonine kinase B. | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.995 |