node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cplx1 | Cplx3 | ENSRNOP00000058432 | ENSRNOP00000026165 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Similar to Complexin III (Predicted). | 0.685 |
Cplx1 | Snap23 | ENSRNOP00000058432 | ENSRNOP00000064401 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | 0.973 |
Cplx1 | Snap25 | ENSRNOP00000058432 | ENSRNOP00000007998 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.963 |
Cplx1 | Stx1a | ENSRNOP00000058432 | ENSRNOP00000040699 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.995 |
Cplx1 | Stx1b | ENSRNOP00000058432 | ENSRNOP00000026063 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm (By similarity). | 0.801 |
Cplx1 | Stx3 | ENSRNOP00000058432 | ENSRNOP00000028535 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones. | 0.845 |
Cplx1 | Vamp1 | ENSRNOP00000058432 | ENSRNOP00000025081 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. | 0.857 |
Cplx1 | Vamp2 | ENSRNOP00000058432 | ENSRNOP00000054114 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane (Probable). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 ; Belongs to the synaptobrevin family. | 0.994 |
Cplx3 | Cplx1 | ENSRNOP00000026165 | ENSRNOP00000058432 | Similar to Complexin III (Predicted). | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. Belongs to the complexin/synaphin family. | 0.685 |
Cplx3 | Moxd1 | ENSRNOP00000026165 | ENSRNOP00000057945 | Similar to Complexin III (Predicted). | Monooxygenase, DBH-like 1. | 0.680 |
Cplx3 | Nxph4 | ENSRNOP00000026165 | ENSRNOP00000050310 | Similar to Complexin III (Predicted). | Neurexophilin-4; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | 0.660 |
Cplx3 | Snap23 | ENSRNOP00000026165 | ENSRNOP00000064401 | Similar to Complexin III (Predicted). | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; Belongs to the SNAP-25 family. | 0.679 |
Cplx3 | Snap25 | ENSRNOP00000026165 | ENSRNOP00000007998 | Similar to Complexin III (Predicted). | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.760 |
Cplx3 | Stx1a | ENSRNOP00000026165 | ENSRNOP00000040699 | Similar to Complexin III (Predicted). | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.852 |
Cplx3 | Stx1b | ENSRNOP00000026165 | ENSRNOP00000026063 | Similar to Complexin III (Predicted). | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm (By similarity). | 0.656 |
Cplx3 | Stx3 | ENSRNOP00000026165 | ENSRNOP00000028535 | Similar to Complexin III (Predicted). | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones. | 0.652 |
Cplx3 | Vamp1 | ENSRNOP00000026165 | ENSRNOP00000025081 | Similar to Complexin III (Predicted). | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. | 0.743 |
Cplx3 | Vamp2 | ENSRNOP00000026165 | ENSRNOP00000054114 | Similar to Complexin III (Predicted). | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane (Probable). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 ; Belongs to the synaptobrevin family. | 0.729 |
Moxd1 | Cplx3 | ENSRNOP00000057945 | ENSRNOP00000026165 | Monooxygenase, DBH-like 1. | Similar to Complexin III (Predicted). | 0.680 |
Nxph4 | Cplx3 | ENSRNOP00000050310 | ENSRNOP00000026165 | Neurexophilin-4; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family. | Similar to Complexin III (Predicted). | 0.660 |