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Slx1b protein (Rattus norvegicus) - STRING interaction network
"Slx1b" - Structure-specific endonuclease subunit SLX1 in Rattus norvegicus
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
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[Homology]
Score
Slx1bStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5’-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products (271 aa)    
Predicted Functional Partners:
Mus81
Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5’-end at the branch nick. Typical substrates include 3’-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family (551 aa)
     
  0.996
Eme1
Essential meiotic structure-specific endonuclease 1 (569 aa)
     
  0.993
Slx4
SLX4 structure-specific endonuclease subunit (1539 aa)
       
  0.992
Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit; Excision repair cross-complementing rodent repair deficiency, complementation group 1 (298 aa)
     
  0.989
Rmi1
RecQ mediated genome instability 1 (617 aa)
     
  0.987
Blm
Bloom syndrome, RecQ helicase-like (1404 aa)
     
  0.986
Exo1
Exonuclease 1 (836 aa)
     
 
  0.985
RGD1564719
Fanconi anemia core complex-associated protein 24; Similar to RIKEN cDNA C230052I12 (221 aa)
     
  0.981
ENSRNOG00000046770
Uncharacterized protein; Excision repair cross-complementation group 4 (914 aa)
     
  0.980
Ercc4
ERCC excision repair 4, endonuclease catalytic subunit; Excision repair cross-complementation group 4 (917 aa)
     
  0.980
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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