node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arpc4 | Slx1b | ENSRNOP00000011937 | ENSRNOP00000026231 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.911 |
Eme1 | Ercc1 | ENSRNOP00000029101 | ENSRNOP00000024113 | Essential meiotic structure-specific endonuclease 1. | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.828 |
Eme1 | Ercc4 | ENSRNOP00000029101 | ENSRNOP00000004563 | Essential meiotic structure-specific endonuclease 1. | ERCC4 domain-containing protein. | 0.711 |
Eme1 | Faap24 | ENSRNOP00000029101 | ENSRNOP00000031862 | Essential meiotic structure-specific endonuclease 1. | Similar to RIKEN cDNA C230052I12 (Predicted). | 0.785 |
Eme1 | Fancm | ENSRNOP00000029101 | ENSRNOP00000074177 | Essential meiotic structure-specific endonuclease 1. | FA complementation group M. | 0.768 |
Eme1 | Mus81 | ENSRNOP00000029101 | ENSRNOP00000028015 | Essential meiotic structure-specific endonuclease 1. | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.999 |
Eme1 | Rmi1 | ENSRNOP00000029101 | ENSRNOP00000025812 | Essential meiotic structure-specific endonuclease 1. | RecQ mediated genome instability 1. | 0.726 |
Eme1 | Slx1b | ENSRNOP00000029101 | ENSRNOP00000026231 | Essential meiotic structure-specific endonuclease 1. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.949 |
Eme1 | Slx4 | ENSRNOP00000029101 | ENSRNOP00000031220 | Essential meiotic structure-specific endonuclease 1. | SLX4 structure-specific endonuclease subunit. | 0.976 |
Eme1 | Wrn | ENSRNOP00000029101 | ENSRNOP00000055596 | Essential meiotic structure-specific endonuclease 1. | WRN RecQ-like helicase. | 0.676 |
Ercc1 | Eme1 | ENSRNOP00000024113 | ENSRNOP00000029101 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Essential meiotic structure-specific endonuclease 1. | 0.828 |
Ercc1 | Ercc4 | ENSRNOP00000024113 | ENSRNOP00000004563 | ERCC excision repair 1, endonuclease non-catalytic subunit. | ERCC4 domain-containing protein. | 0.999 |
Ercc1 | Faap24 | ENSRNOP00000024113 | ENSRNOP00000031862 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Similar to RIKEN cDNA C230052I12 (Predicted). | 0.813 |
Ercc1 | Fancm | ENSRNOP00000024113 | ENSRNOP00000074177 | ERCC excision repair 1, endonuclease non-catalytic subunit. | FA complementation group M. | 0.994 |
Ercc1 | Mus81 | ENSRNOP00000024113 | ENSRNOP00000028015 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.957 |
Ercc1 | Rmi1 | ENSRNOP00000024113 | ENSRNOP00000025812 | ERCC excision repair 1, endonuclease non-catalytic subunit. | RecQ mediated genome instability 1. | 0.586 |
Ercc1 | Slx1b | ENSRNOP00000024113 | ENSRNOP00000026231 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. | 0.943 |
Ercc1 | Slx4 | ENSRNOP00000024113 | ENSRNOP00000031220 | ERCC excision repair 1, endonuclease non-catalytic subunit. | SLX4 structure-specific endonuclease subunit. | 0.975 |
Ercc1 | Wrn | ENSRNOP00000024113 | ENSRNOP00000055596 | ERCC excision repair 1, endonuclease non-catalytic subunit. | WRN RecQ-like helicase. | 0.803 |
Ercc4 | Eme1 | ENSRNOP00000004563 | ENSRNOP00000029101 | ERCC4 domain-containing protein. | Essential meiotic structure-specific endonuclease 1. | 0.711 |