node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Inpp1 | Inpp5a | ENSRNOP00000016842 | ENSRNOP00000051774 | Inositol polyphosphate-1-phosphatase. | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | 0.925 |
Inpp1 | Inpp5j | ENSRNOP00000016842 | ENSRNOP00000026293 | Inositol polyphosphate-1-phosphatase. | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | 0.956 |
Inpp1 | Inpp5k | ENSRNOP00000016842 | ENSRNOP00000073462 | Inositol polyphosphate-1-phosphatase. | Inositol polyphosphate-5-phosphatase K. | 0.926 |
Inpp1 | Minpp1 | ENSRNOP00000016842 | ENSRNOP00000015017 | Inositol polyphosphate-1-phosphatase. | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3- bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity); Belongs [...] | 0.484 |
Inpp1 | Plce1 | ENSRNOP00000016842 | ENSRNOP00000072165 | Inositol polyphosphate-1-phosphatase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. | 0.901 |
Inpp5a | Inpp1 | ENSRNOP00000051774 | ENSRNOP00000016842 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Inositol polyphosphate-1-phosphatase. | 0.925 |
Inpp5a | Inpp5j | ENSRNOP00000051774 | ENSRNOP00000026293 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | 0.951 |
Inpp5a | Inpp5k | ENSRNOP00000051774 | ENSRNOP00000073462 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Inositol polyphosphate-5-phosphatase K. | 0.964 |
Inpp5a | Ipmk | ENSRNOP00000051774 | ENSRNOP00000000748 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6- pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphospha [...] | 0.911 |
Inpp5a | Itpka | ENSRNOP00000051774 | ENSRNOP00000007247 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Inositol-trisphosphate 3-kinase A; Belongs to the inositol phosphokinase (IPK) family. | 0.944 |
Inpp5a | Itpkb | ENSRNOP00000051774 | ENSRNOP00000004032 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Inositol-trisphosphate 3-kinase B. | 0.959 |
Inpp5a | Itpkc | ENSRNOP00000051774 | ENSRNOP00000018696 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate; Belongs to the inositol phosphokinase (IPK) family. | 0.949 |
Inpp5a | Minpp1 | ENSRNOP00000051774 | ENSRNOP00000015017 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3- bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity); Belongs [...] | 0.926 |
Inpp5a | Plce1 | ENSRNOP00000051774 | ENSRNOP00000072165 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation. | 0.953 |
Inpp5j | Inpp1 | ENSRNOP00000026293 | ENSRNOP00000016842 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | Inositol polyphosphate-1-phosphatase. | 0.956 |
Inpp5j | Inpp5a | ENSRNOP00000026293 | ENSRNOP00000051774 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | 0.951 |
Inpp5j | Inpp5k | ENSRNOP00000026293 | ENSRNOP00000073462 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | Inositol polyphosphate-5-phosphatase K. | 0.903 |
Inpp5j | Ipmk | ENSRNOP00000026293 | ENSRNOP00000000748 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | Inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6- pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphospha [...] | 0.906 |
Inpp5j | Itpka | ENSRNOP00000026293 | ENSRNOP00000007247 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | Inositol-trisphosphate 3-kinase A; Belongs to the inositol phosphokinase (IPK) family. | 0.935 |
Inpp5j | Itpkb | ENSRNOP00000026293 | ENSRNOP00000004032 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. | Inositol-trisphosphate 3-kinase B. | 0.932 |