node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dnajb2 | Dnajc6 | ENSRNOP00000074369 | ENSRNOP00000070493 | DnaJ heat shock protein family (Hsp40) member B2. | DnaJ heat shock protein family (Hsp40) member C6. | 0.742 |
Dnajb2 | Hspa1b | ENSRNOP00000074369 | ENSRNOP00000075599 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock protein family A (Hsp70) member 1B. | 0.776 |
Dnajb2 | Hspa4 | ENSRNOP00000074369 | ENSRNOP00000023628 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.847 |
Dnajb2 | Hspa4l | ENSRNOP00000074369 | ENSRNOP00000015474 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock 70 kDa protein 4L. | 0.769 |
Dnajb2 | Hspa5 | ENSRNOP00000074369 | ENSRNOP00000025064 | DnaJ heat shock protein family (Hsp40) member B2. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.759 |
Dnajb2 | Hspa8 | ENSRNOP00000074369 | ENSRNOP00000042159 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. | 0.804 |
Dnajb2 | Hspa9 | ENSRNOP00000074369 | ENSRNOP00000026696 | DnaJ heat shock protein family (Hsp40) member B2. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | 0.727 |
Dnajb2 | Hspb8 | ENSRNOP00000074369 | ENSRNOP00000033432 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock protein beta-8; Displays temperature-dependent chaperone activity. | 0.763 |
Dnajb2 | Hsph1 | ENSRNOP00000074369 | ENSRNOP00000001201 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.854 |
Dnajb2 | LOC680121 | ENSRNOP00000074369 | ENSRNOP00000058593 | DnaJ heat shock protein family (Hsp40) member B2. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.802 |
Dnajc6 | Dnajb2 | ENSRNOP00000070493 | ENSRNOP00000074369 | DnaJ heat shock protein family (Hsp40) member C6. | DnaJ heat shock protein family (Hsp40) member B2. | 0.742 |
Dnajc6 | Hspa1b | ENSRNOP00000070493 | ENSRNOP00000075599 | DnaJ heat shock protein family (Hsp40) member C6. | Heat shock protein family A (Hsp70) member 1B. | 0.584 |
Dnajc6 | Hspa4 | ENSRNOP00000070493 | ENSRNOP00000023628 | DnaJ heat shock protein family (Hsp40) member C6. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.623 |
Dnajc6 | Hspa4l | ENSRNOP00000070493 | ENSRNOP00000015474 | DnaJ heat shock protein family (Hsp40) member C6. | Heat shock 70 kDa protein 4L. | 0.534 |
Dnajc6 | Hspa5 | ENSRNOP00000070493 | ENSRNOP00000025064 | DnaJ heat shock protein family (Hsp40) member C6. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.409 |
Dnajc6 | Hspa8 | ENSRNOP00000070493 | ENSRNOP00000042159 | DnaJ heat shock protein family (Hsp40) member C6. | Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. | 0.799 |
Dnajc6 | Hspa9 | ENSRNOP00000070493 | ENSRNOP00000026696 | DnaJ heat shock protein family (Hsp40) member C6. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. | 0.449 |
Dnajc6 | Hsph1 | ENSRNOP00000070493 | ENSRNOP00000001201 | DnaJ heat shock protein family (Hsp40) member C6. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.578 |
Dnajc6 | LOC680121 | ENSRNOP00000070493 | ENSRNOP00000058593 | DnaJ heat shock protein family (Hsp40) member C6. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.978 |
Hspa1b | Dnajb2 | ENSRNOP00000075599 | ENSRNOP00000074369 | Heat shock protein family A (Hsp70) member 1B. | DnaJ heat shock protein family (Hsp40) member B2. | 0.776 |