STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Coro1aCoronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. (461 aa)    
Predicted Functional Partners:
Laptm5
Lysosomal-associated protein transmembrane 5.
   
  
 0.819
Was
WASP actin nucleation-promoting factor.
   
 
 0.777
Cfl2
Cofilin 2, muscle (Predicted), isoform CRA_b; Belongs to the actin-binding proteins ADF family.
   
 
 0.733
Tyrobp
TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]
   
  
 0.732
Ncf4
Similar to neutrophil cytosolic factor 4, isoform CRA_a.
   
  
 0.723
Arhgap30
Similar to RIKEN cDNA 6030405P05 gene (Predicted).
   
  
 0.703
Itgb2
Integrin beta.
   
  
 0.678
Rac2
Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2).
   
 
 0.646
Fermt3
Fermitin family member 3.
   
  
 0.610
Arhgap4
Rho GTPase activating protein 4, isoform CRA_a.
   
  
 0.609
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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