node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A0G2JZ02_RAT | Dph2 | ENSRNOP00000070859 | ENSRNOP00000026739 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2); Belongs to the DPH1/DPH2 family. DPH2 subfamily. | 0.732 |
A0A0G2JZ02_RAT | Dph6 | ENSRNOP00000070859 | ENSRNOP00000053362 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). | 0.637 |
Atp6v0b | Dph2 | ENSRNOP00000026704 | ENSRNOP00000026739 | ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a; Belongs to the V-ATPase proteolipid subunit family. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2); Belongs to the DPH1/DPH2 family. DPH2 subfamily. | 0.740 |
Atp6v0b | Eef2 | ENSRNOP00000026704 | ENSRNOP00000041821 | ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a; Belongs to the V-ATPase proteolipid subunit family. | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.491 |
Ddx31 | Dph1 | ENSRNOP00000061319 | ENSRNOP00000072126 | RNA helicase. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | 0.439 |
Ddx31 | Dph2 | ENSRNOP00000061319 | ENSRNOP00000026739 | RNA helicase. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2); Belongs to the DPH1/DPH2 family. DPH2 subfamily. | 0.764 |
Ddx31 | Eef2 | ENSRNOP00000061319 | ENSRNOP00000041821 | RNA helicase. | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.451 |
Dnajc24 | Dph1 | ENSRNOP00000006431 | ENSRNOP00000072126 | DnaJ heat shock protein family (Hsp40) member C24. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | 0.805 |
Dnajc24 | Dph2 | ENSRNOP00000006431 | ENSRNOP00000026739 | DnaJ heat shock protein family (Hsp40) member C24. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2); Belongs to the DPH1/DPH2 family. DPH2 subfamily. | 0.818 |
Dnajc24 | Dph3 | ENSRNOP00000006431 | ENSRNOP00000026742 | DnaJ heat shock protein family (Hsp40) member C24. | Diphthamide biosynthesis 3. | 0.808 |
Dnajc24 | Dph5 | ENSRNOP00000006431 | ENSRNOP00000018367 | DnaJ heat shock protein family (Hsp40) member C24. | DPH5 homolog (S. cerevisiae), isoform CRA_b. | 0.767 |
Dnajc24 | Dph6 | ENSRNOP00000006431 | ENSRNOP00000053362 | DnaJ heat shock protein family (Hsp40) member C24. | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). | 0.647 |
Dnajc24 | Dph7 | ENSRNOP00000006431 | ENSRNOP00000040931 | DnaJ heat shock protein family (Hsp40) member C24. | Diphthamide biosynthesis 7. | 0.668 |
Dnajc24 | Eef2 | ENSRNOP00000006431 | ENSRNOP00000041821 | DnaJ heat shock protein family (Hsp40) member C24. | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.852 |
Dph1 | Ddx31 | ENSRNOP00000072126 | ENSRNOP00000061319 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | RNA helicase. | 0.439 |
Dph1 | Dnajc24 | ENSRNOP00000072126 | ENSRNOP00000006431 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | DnaJ heat shock protein family (Hsp40) member C24. | 0.805 |
Dph1 | Dph2 | ENSRNOP00000072126 | ENSRNOP00000026739 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2); Belongs to the DPH1/DPH2 family. DPH2 subfamily. | 0.995 |
Dph1 | Dph3 | ENSRNOP00000072126 | ENSRNOP00000026742 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | Diphthamide biosynthesis 3. | 0.991 |
Dph1 | Dph5 | ENSRNOP00000072126 | ENSRNOP00000018367 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | DPH5 homolog (S. cerevisiae), isoform CRA_b. | 0.946 |
Dph1 | Dph6 | ENSRNOP00000072126 | ENSRNOP00000053362 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). | 0.799 |