STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Resp18Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. (206 aa)    
Predicted Functional Partners:
Pcsk2
Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily.
   
  
 0.616
Chgb
CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
   
  
 0.536
Scg2
Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
   
  
 0.507
rCG_33321
RCG33321, isoform CRA_b.
      
 0.505
Tor2a
Torsin-2A.
      
 0.495
Lrrn2
Leucine-rich repeat neuronal 2.
   
 
 0.478
Fabp9
Fatty acid-binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
      
 0.475
Tmem130
Transmembrane protein 130.
   
  
 0.456
Chga
p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...]
   
  
 0.444
Cartpt
Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.
   
  
 0.418
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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