node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cartpt | Resp18 | ENSRNOP00000023869 | ENSRNOP00000071007 | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.418 |
Cartpt | Scg2 | ENSRNOP00000023869 | ENSRNOP00000020219 | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.425 |
Chga | Chgb | ENSRNOP00000070296 | ENSRNOP00000028892 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.990 |
Chga | Pcsk2 | ENSRNOP00000070296 | ENSRNOP00000007249 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | 0.638 |
Chga | Resp18 | ENSRNOP00000070296 | ENSRNOP00000071007 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.444 |
Chga | Scg2 | ENSRNOP00000070296 | ENSRNOP00000020219 | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.899 |
Chgb | Chga | ENSRNOP00000028892 | ENSRNOP00000070296 | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | 0.990 |
Chgb | Pcsk2 | ENSRNOP00000028892 | ENSRNOP00000007249 | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | 0.696 |
Chgb | Resp18 | ENSRNOP00000028892 | ENSRNOP00000071007 | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.536 |
Chgb | Scg2 | ENSRNOP00000028892 | ENSRNOP00000020219 | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.968 |
Fabp9 | Resp18 | ENSRNOP00000014949 | ENSRNOP00000071007 | Fatty acid-binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.475 |
Lrrn2 | Resp18 | ENSRNOP00000012844 | ENSRNOP00000071007 | Leucine-rich repeat neuronal 2. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.478 |
Pcsk2 | Chga | ENSRNOP00000007249 | ENSRNOP00000070296 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | 0.638 |
Pcsk2 | Chgb | ENSRNOP00000007249 | ENSRNOP00000028892 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.696 |
Pcsk2 | Resp18 | ENSRNOP00000007249 | ENSRNOP00000071007 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.616 |
Pcsk2 | Scg2 | ENSRNOP00000007249 | ENSRNOP00000020219 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.569 |
Resp18 | Cartpt | ENSRNOP00000071007 | ENSRNOP00000023869 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. | 0.418 |
Resp18 | Chga | ENSRNOP00000071007 | ENSRNOP00000070296 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAM [...] | 0.444 |
Resp18 | Chgb | ENSRNOP00000071007 | ENSRNOP00000028892 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | CCB peptide short form; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.536 |
Resp18 | Fabp9 | ENSRNOP00000071007 | ENSRNOP00000014949 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | Fatty acid-binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.475 |