node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Egfr | Jak1 | ENSRNOP00000006087 | ENSRNOP00000061649 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.952 |
Egfr | Jak2 | ENSRNOP00000006087 | ENSRNOP00000071877 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.969 |
Egfr | Jak3 | ENSRNOP00000006087 | ENSRNOP00000025312 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] | 0.954 |
Egfr | Nanog | ENSRNOP00000006087 | ENSRNOP00000063016 | Receptor protein-tyrosine kinase. | Nanog homeobox. | 0.557 |
Egfr | Src | ENSRNOP00000006087 | ENSRNOP00000071837 | Receptor protein-tyrosine kinase. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.999 |
Egfr | Stat1 | ENSRNOP00000006087 | ENSRNOP00000070183 | Receptor protein-tyrosine kinase. | Signal transducer and activator of transcription. | 0.875 |
Egfr | Stat3 | ENSRNOP00000006087 | ENSRNOP00000026760 | Receptor protein-tyrosine kinase. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.993 |
Egfr | Tyk2 | ENSRNOP00000006087 | ENSRNOP00000048018 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.828 |
Irf9 | Jak1 | ENSRNOP00000026364 | ENSRNOP00000061649 | Interferon regulatory factor 9. | Tyrosine-protein kinase. | 0.988 |
Irf9 | Jak2 | ENSRNOP00000026364 | ENSRNOP00000071877 | Interferon regulatory factor 9. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.466 |
Irf9 | Stat1 | ENSRNOP00000026364 | ENSRNOP00000070183 | Interferon regulatory factor 9. | Signal transducer and activator of transcription. | 0.999 |
Irf9 | Stat3 | ENSRNOP00000026364 | ENSRNOP00000026760 | Interferon regulatory factor 9. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.989 |
Irf9 | Tyk2 | ENSRNOP00000026364 | ENSRNOP00000048018 | Interferon regulatory factor 9. | Tyrosine-protein kinase. | 0.986 |
Jak1 | Egfr | ENSRNOP00000061649 | ENSRNOP00000006087 | Tyrosine-protein kinase. | Receptor protein-tyrosine kinase. | 0.952 |
Jak1 | Irf9 | ENSRNOP00000061649 | ENSRNOP00000026364 | Tyrosine-protein kinase. | Interferon regulatory factor 9. | 0.988 |
Jak1 | Jak2 | ENSRNOP00000061649 | ENSRNOP00000071877 | Tyrosine-protein kinase. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.990 |
Jak1 | Jak3 | ENSRNOP00000061649 | ENSRNOP00000025312 | Tyrosine-protein kinase. | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] | 0.992 |
Jak1 | Pias3 | ENSRNOP00000061649 | ENSRNOP00000028814 | Tyrosine-protein kinase. | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which pro [...] | 0.429 |
Jak1 | Stat1 | ENSRNOP00000061649 | ENSRNOP00000070183 | Tyrosine-protein kinase. | Signal transducer and activator of transcription. | 0.999 |
Jak1 | Stat3 | ENSRNOP00000061649 | ENSRNOP00000026760 | Tyrosine-protein kinase. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.999 |