node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ddrgk1 | Rit2 | ENSRNOP00000036810 | ENSRNOP00000023871 | Similar to chromosome 20 open reading frame 116 (Predicted). | GTP-binding protein Rit2; Binds and exchanges GTP and GDP; Belongs to the small GTPase superfamily. Ras family. | 0.571 |
Ddrgk1 | Sipa1l2 | ENSRNOP00000036810 | ENSRNOP00000026843 | Similar to chromosome 20 open reading frame 116 (Predicted). | Signal-induced proliferation-associated 1-like protein 2. | 0.521 |
Ddrgk1 | Tmem175 | ENSRNOP00000036810 | ENSRNOP00000000050 | Similar to chromosome 20 open reading frame 116 (Predicted). | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Belongs to the TMEM175 family. | 0.435 |
Farp1 | Sipa1l2 | ENSRNOP00000015271 | ENSRNOP00000026843 | FERM, ARHGEF and pleckstrin domain-containing protein 1; May play a role in semaphorin signaling (By similarity). Functions as guanine nucleotide exchange factor for RAC1. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses. | Signal-induced proliferation-associated 1-like protein 2. | 0.497 |
Lzts2 | Sipa1l2 | ENSRNOP00000042095 | ENSRNOP00000026843 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. | Signal-induced proliferation-associated 1-like protein 2. | 0.478 |
Lzts3 | Sipa1l2 | ENSRNOP00000028835 | ENSRNOP00000026843 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. | Signal-induced proliferation-associated 1-like protein 2. | 0.640 |
Rap1a | Rap1b | ENSRNOP00000040409 | ENSRNOP00000009511 | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular [...] | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. | 0.910 |
Rap1a | Sipa1l2 | ENSRNOP00000040409 | ENSRNOP00000026843 | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular [...] | Signal-induced proliferation-associated 1-like protein 2. | 0.915 |
Rap1b | Rap1a | ENSRNOP00000009511 | ENSRNOP00000040409 | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular [...] | 0.910 |
Rap1b | Sipa1l2 | ENSRNOP00000009511 | ENSRNOP00000026843 | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. | Signal-induced proliferation-associated 1-like protein 2. | 0.927 |
Rit2 | Ddrgk1 | ENSRNOP00000023871 | ENSRNOP00000036810 | GTP-binding protein Rit2; Binds and exchanges GTP and GDP; Belongs to the small GTPase superfamily. Ras family. | Similar to chromosome 20 open reading frame 116 (Predicted). | 0.571 |
Rit2 | Sipa1l2 | ENSRNOP00000023871 | ENSRNOP00000026843 | GTP-binding protein Rit2; Binds and exchanges GTP and GDP; Belongs to the small GTPase superfamily. Ras family. | Signal-induced proliferation-associated 1-like protein 2. | 0.585 |
Rit2 | Tmem175 | ENSRNOP00000023871 | ENSRNOP00000000050 | GTP-binding protein Rit2; Binds and exchanges GTP and GDP; Belongs to the small GTPase superfamily. Ras family. | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Belongs to the TMEM175 family. | 0.432 |
Rit2 | Tmem229b | ENSRNOP00000023871 | ENSRNOP00000014132 | GTP-binding protein Rit2; Binds and exchanges GTP and GDP; Belongs to the small GTPase superfamily. Ras family. | Transmembrane protein 229B. | 0.475 |
Sipa1l2 | Ddrgk1 | ENSRNOP00000026843 | ENSRNOP00000036810 | Signal-induced proliferation-associated 1-like protein 2. | Similar to chromosome 20 open reading frame 116 (Predicted). | 0.521 |
Sipa1l2 | Farp1 | ENSRNOP00000026843 | ENSRNOP00000015271 | Signal-induced proliferation-associated 1-like protein 2. | FERM, ARHGEF and pleckstrin domain-containing protein 1; May play a role in semaphorin signaling (By similarity). Functions as guanine nucleotide exchange factor for RAC1. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses. | 0.497 |
Sipa1l2 | Lzts2 | ENSRNOP00000026843 | ENSRNOP00000042095 | Signal-induced proliferation-associated 1-like protein 2. | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. | 0.478 |
Sipa1l2 | Lzts3 | ENSRNOP00000026843 | ENSRNOP00000028835 | Signal-induced proliferation-associated 1-like protein 2. | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. | 0.640 |
Sipa1l2 | Rap1a | ENSRNOP00000026843 | ENSRNOP00000040409 | Signal-induced proliferation-associated 1-like protein 2. | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular [...] | 0.915 |
Sipa1l2 | Rap1b | ENSRNOP00000026843 | ENSRNOP00000009511 | Signal-induced proliferation-associated 1-like protein 2. | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. | 0.927 |