STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DrgxDorsal root ganglia homeobox protein; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. (263 aa)    
Predicted Functional Partners:
Prdm12
PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily.
    
 
 0.706
Rgma
RGM domain family, member A (Predicted), isoform CRA_a.
      
 0.583
Skor2
SKI family transcriptional corepressor 2.
   
  
 0.568
Pou4f1
POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N- terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects ne [...]
   
 
 0.554
Zmat1
Zinc finger, matrin-type 1.
   
  
 0.548
Rgmb
Repulsive guidance molecule BMP co-receptor b.
      
 0.510
Aebp2
AE binding protein 2 (Predicted).
   
 
 0.488
Aamp
Angio-associated migratory protein (Predicted).
   
  
 0.463
Ldb2
LIM domain-binding 2.
    
 
 0.425
Cpn2
Carboxypeptidase N subunit 2.
    
 
 0.420
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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