STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Art1NAD(P)(+)--arginine ADP-ribosyltransferase. (321 aa)    
Predicted Functional Partners:
Art5
Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family.
   
  
0.612
Adprh
[Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
   
  
 0.492
P2rx7
P2X purinoceptor 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
      
 0.465
Defa24
Defensin 5; Probably contributes to the antimicrobial barrier function of the small intestine; Belongs to the alpha-defensin family.
     
 0.456
Defal1
Defensin alpha-like protein 1; Intestinal defense peptide. Has potent antibacterial activity against Gram- negative bacteria E.coli O157:H7, S.typhimurium DT104, and K.pneumoniae; and against Gram-positive bacteria S.aureus, methicillin- resistant S.aureus and L.monocytogenes. Remains active in the presence of NaCl and Mg(2+). Probably functions by disrupting bacterial membrane integrity. However, does not show cytotoxic activity towards human intestinal cells. Belongs to the alpha-defensin family.
   
 
 0.446
Defa5
Neutrophil antibiotic peptide NP-2; Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.
     
 0.443
Defa9
Defensin alpha 9.
     
 0.443
Defa8
Defensin alpha 8.
     
 0.443
Defa6
Defensin alpha 6.
     
 0.443
Defa11
Defensin alpha 11.
     
 0.443
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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