STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ptov1Prostate tumor-overexpressed gene 1 protein homolog; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity). (416 aa)    
Predicted Functional Partners:
Fancm
FA complementation group M.
   
 
 0.726
D430019H16Rik
RIKEN cDNA D430019H16 gene.
      
 0.645
Ssbp4
Similar to RIKEN cDNA 1210002E11, isoform CRA_c.
   
  
 0.587
Lrch4
Leucine-rich repeats and calponin homology domain-containing 4.
    
 
 0.571
Guca1a
Guanylate cyclase activator 1a (Retina) (Predicted), isoform CRA_a.
    
 
 0.571
Flot1
Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
   
 
 0.567
Jmjd6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...]
      
 0.559
Ahsa1
Activator of Hsp90 ATPase activity 1.
   
  
 0.540
Tm9sf4
Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
   
  
 0.533
Gramd1c
GRAM domain-containing 1C.
      
 0.499
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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