node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgdia | Arhgdib | ENSRNOP00000051840 | ENSRNOP00000007779 | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] | Rho, GDP dissociation inhibitor (GDI) beta, isoform CRA_a. | 0.902 |
Arhgdia | Itsn1 | ENSRNOP00000051840 | ENSRNOP00000044773 | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.420 |
Arhgdia | Rhog | ENSRNOP00000051840 | ENSRNOP00000027641 | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] | Ras homolog gene family, member G (Rho G). | 0.936 |
Arhgdib | Arhgdia | ENSRNOP00000007779 | ENSRNOP00000051840 | Rho, GDP dissociation inhibitor (GDI) beta, isoform CRA_a. | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] | 0.902 |
Arhgdib | Rhog | ENSRNOP00000007779 | ENSRNOP00000027641 | Rho, GDP dissociation inhibitor (GDI) beta, isoform CRA_a. | Ras homolog gene family, member G (Rho G). | 0.890 |
Arhgef26 | Rhog | ENSRNOP00000019554 | ENSRNOP00000027641 | Rho guanine nucleotide exchange factor 26. | Ras homolog gene family, member G (Rho G). | 0.972 |
Dock1 | Elmo1 | ENSRNOP00000051781 | ENSRNOP00000073656 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Engulfment and cell motility 1 splice 1 variant. | 0.998 |
Dock1 | Elmo2 | ENSRNOP00000051781 | ENSRNOP00000039023 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | 0.996 |
Dock1 | Elmo3 | ENSRNOP00000051781 | ENSRNOP00000021362 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | 0.969 |
Dock1 | Rhog | ENSRNOP00000051781 | ENSRNOP00000027641 | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | Ras homolog gene family, member G (Rho G). | 0.984 |
Elmo1 | Dock1 | ENSRNOP00000073656 | ENSRNOP00000051781 | Engulfment and cell motility 1 splice 1 variant. | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | 0.998 |
Elmo1 | Elmo2 | ENSRNOP00000073656 | ENSRNOP00000039023 | Engulfment and cell motility 1 splice 1 variant. | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | 0.952 |
Elmo1 | Elmo3 | ENSRNOP00000073656 | ENSRNOP00000021362 | Engulfment and cell motility 1 splice 1 variant. | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | 0.953 |
Elmo1 | Rhog | ENSRNOP00000073656 | ENSRNOP00000027641 | Engulfment and cell motility 1 splice 1 variant. | Ras homolog gene family, member G (Rho G). | 0.995 |
Elmo2 | Dock1 | ENSRNOP00000039023 | ENSRNOP00000051781 | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | 0.996 |
Elmo2 | Elmo1 | ENSRNOP00000039023 | ENSRNOP00000073656 | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | Engulfment and cell motility 1 splice 1 variant. | 0.952 |
Elmo2 | Elmo3 | ENSRNOP00000039023 | ENSRNOP00000021362 | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | 0.950 |
Elmo2 | Rhog | ENSRNOP00000039023 | ENSRNOP00000027641 | Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b. | Ras homolog gene family, member G (Rho G). | 0.995 |
Elmo3 | Dock1 | ENSRNOP00000021362 | ENSRNOP00000051781 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | Dedicator of cyto-kinesis 1; Belongs to the DOCK family. | 0.969 |
Elmo3 | Elmo1 | ENSRNOP00000021362 | ENSRNOP00000073656 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). | Engulfment and cell motility 1 splice 1 variant. | 0.953 |