node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cbx1 | Trim28 | ENSRNOP00000011665 | ENSRNOP00000031061 | RCG35120, isoform CRA_a. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.890 |
Cbx1 | Zfp382 | ENSRNOP00000011665 | ENSRNOP00000028187 | RCG35120, isoform CRA_a. | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.402 |
Ccdc146 | Zfp382 | ENSRNOP00000017374 | ENSRNOP00000028187 | Coiled-coil domain-containing protein 146. | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.456 |
Dvl2 | Fzd1 | ENSRNOP00000024348 | ENSRNOP00000021979 | Dishevelled segment polarity protein 2. | Frizzled-1; Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family mem [...] | 0.896 |
Dvl2 | Zfp382 | ENSRNOP00000024348 | ENSRNOP00000028187 | Dishevelled segment polarity protein 2. | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.422 |
Ergic2 | Zfp382 | ENSRNOP00000070726 | ENSRNOP00000028187 | RCG29652, isoform CRA_c. | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.412 |
Fzd1 | Dvl2 | ENSRNOP00000021979 | ENSRNOP00000024348 | Frizzled-1; Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family mem [...] | Dishevelled segment polarity protein 2. | 0.896 |
Fzd1 | Zfp382 | ENSRNOP00000021979 | ENSRNOP00000028187 | Frizzled-1; Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family mem [...] | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.469 |
Gna14 | Zfp382 | ENSRNOP00000020201 | ENSRNOP00000028187 | Guanine nucleotide binding protein, alpha 14, isoform CRA_a. | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.441 |
Jun | Zfp382 | ENSRNOP00000011732 | ENSRNOP00000028187 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.404 |
Trim28 | Cbx1 | ENSRNOP00000031061 | ENSRNOP00000011665 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | RCG35120, isoform CRA_a. | 0.890 |
Trim28 | Zfp382 | ENSRNOP00000031061 | ENSRNOP00000028187 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | 0.796 |
Zfp382 | Cbx1 | ENSRNOP00000028187 | ENSRNOP00000011665 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | RCG35120, isoform CRA_a. | 0.402 |
Zfp382 | Ccdc146 | ENSRNOP00000028187 | ENSRNOP00000017374 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | Coiled-coil domain-containing protein 146. | 0.456 |
Zfp382 | Dvl2 | ENSRNOP00000028187 | ENSRNOP00000024348 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | Dishevelled segment polarity protein 2. | 0.422 |
Zfp382 | Ergic2 | ENSRNOP00000028187 | ENSRNOP00000070726 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | RCG29652, isoform CRA_c. | 0.412 |
Zfp382 | Fzd1 | ENSRNOP00000028187 | ENSRNOP00000021979 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | Frizzled-1; Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family mem [...] | 0.469 |
Zfp382 | Gna14 | ENSRNOP00000028187 | ENSRNOP00000020201 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | Guanine nucleotide binding protein, alpha 14, isoform CRA_a. | 0.441 |
Zfp382 | Jun | ENSRNOP00000028187 | ENSRNOP00000011732 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. | 0.404 |
Zfp382 | Trim28 | ENSRNOP00000028187 | ENSRNOP00000031061 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.796 |