node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actr6 | Hipk4 | ENSRNOP00000010414 | ENSRNOP00000028266 | ARP6 actin-related protein 6 homolog (Yeast) (Predicted); Belongs to the actin family. | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.684 |
Daxx | Hipk4 | ENSRNOP00000000559 | ENSRNOP00000028266 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.578 |
Daxx | Tp53 | ENSRNOP00000000559 | ENSRNOP00000074031 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.994 |
Dcaf7 | Hipk4 | ENSRNOP00000061467 | ENSRNOP00000028266 | DDB1 and CUL4-associated factor 7. | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.773 |
Hipk4 | Actr6 | ENSRNOP00000028266 | ENSRNOP00000010414 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | ARP6 actin-related protein 6 homolog (Yeast) (Predicted); Belongs to the actin family. | 0.684 |
Hipk4 | Daxx | ENSRNOP00000028266 | ENSRNOP00000000559 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | 0.578 |
Hipk4 | Dcaf7 | ENSRNOP00000028266 | ENSRNOP00000061467 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | DDB1 and CUL4-associated factor 7. | 0.773 |
Hipk4 | Irgq | ENSRNOP00000028266 | ENSRNOP00000071992 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Immunity-related GTPase Q. | 0.583 |
Hipk4 | Rassf5 | ENSRNOP00000028266 | ENSRNOP00000008055 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The [...] | 0.908 |
Hipk4 | Sirt1 | ENSRNOP00000028266 | ENSRNOP00000070943 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...] | 0.568 |
Hipk4 | Spaca1 | ENSRNOP00000028266 | ENSRNOP00000010909 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Similar to RIKEN cDNA 4930540L03 (Predicted). | 0.632 |
Hipk4 | Tp53 | ENSRNOP00000028266 | ENSRNOP00000074031 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.934 |
Hipk4 | Ttc9b | ENSRNOP00000028266 | ENSRNOP00000025472 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Tetratricopeptide repeat domain 9B. | 0.598 |
Hipk4 | Zpbp | ENSRNOP00000028266 | ENSRNOP00000030318 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | Zona pellucida binding protein, isoform CRA_b. | 0.598 |
Irgq | Hipk4 | ENSRNOP00000071992 | ENSRNOP00000028266 | Immunity-related GTPase Q. | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.583 |
Irgq | Ttc9b | ENSRNOP00000071992 | ENSRNOP00000025472 | Immunity-related GTPase Q. | Tetratricopeptide repeat domain 9B. | 0.759 |
Rassf5 | Hipk4 | ENSRNOP00000008055 | ENSRNOP00000028266 | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The [...] | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.908 |
Sirt1 | Hipk4 | ENSRNOP00000070943 | ENSRNOP00000028266 | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...] | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.568 |
Sirt1 | Tp53 | ENSRNOP00000070943 | ENSRNOP00000074031 | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.996 |
Spaca1 | Hipk4 | ENSRNOP00000010909 | ENSRNOP00000028266 | Similar to RIKEN cDNA 4930540L03 (Predicted). | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). | 0.632 |