node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actc1 | Mybpc3 | ENSRNOP00000011773 | ENSRNOP00000016652 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | 0.873 |
Actc1 | Myh6 | ENSRNOP00000011773 | ENSRNOP00000023301 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-6; Muscle contraction. | 0.986 |
Actc1 | Myh7 | ENSRNOP00000011773 | ENSRNOP00000024186 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.983 |
Actc1 | Myl2 | ENSRNOP00000011773 | ENSRNOP00000039707 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.817 |
Actc1 | Myl3 | ENSRNOP00000011773 | ENSRNOP00000028458 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.981 |
Actc1 | Myl4 | ENSRNOP00000011773 | ENSRNOP00000064224 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.966 |
Actc1 | Tnni1 | ENSRNOP00000011773 | ENSRNOP00000067933 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.547 |
LOC103689985 | Myl2 | ENSRNOP00000064869 | ENSRNOP00000039707 | Myosin light chain kinase family, member 4; Belongs to the protein kinase superfamily. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.438 |
LOC103689985 | Myl3 | ENSRNOP00000064869 | ENSRNOP00000028458 | Myosin light chain kinase family, member 4; Belongs to the protein kinase superfamily. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.953 |
LOC103689985 | Myl4 | ENSRNOP00000064869 | ENSRNOP00000064224 | Myosin light chain kinase family, member 4; Belongs to the protein kinase superfamily. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.937 |
Mybpc3 | Actc1 | ENSRNOP00000016652 | ENSRNOP00000011773 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.873 |
Mybpc3 | Myh6 | ENSRNOP00000016652 | ENSRNOP00000023301 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin-6; Muscle contraction. | 0.984 |
Mybpc3 | Myh7 | ENSRNOP00000016652 | ENSRNOP00000024186 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.982 |
Mybpc3 | Myl2 | ENSRNOP00000016652 | ENSRNOP00000039707 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.900 |
Mybpc3 | Myl3 | ENSRNOP00000016652 | ENSRNOP00000028458 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.924 |
Mybpc3 | Myl4 | ENSRNOP00000016652 | ENSRNOP00000064224 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.765 |
Mybpc3 | Mylk3 | ENSRNOP00000016652 | ENSRNOP00000023657 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin light chain kinase 3; Calmodulin-dependent kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes. Increases cardiomyocyte contractility. | 0.452 |
Mybpc3 | Tnni1 | ENSRNOP00000016652 | ENSRNOP00000067933 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.744 |
Myh6 | Actc1 | ENSRNOP00000023301 | ENSRNOP00000011773 | Myosin-6; Muscle contraction. | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.986 |
Myh6 | Mybpc3 | ENSRNOP00000023301 | ENSRNOP00000016652 | Myosin-6; Muscle contraction. | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | 0.984 |