node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyba | Cybb | ENSRNOP00000017564 | ENSRNOP00000031063 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Cytochrome b-245, beta polypeptide, isoform CRA_a. | 0.999 |
Cyba | Duox1 | ENSRNOP00000017564 | ENSRNOP00000045928 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. | 0.971 |
Cyba | Ncf1 | ENSRNOP00000017564 | ENSRNOP00000002028 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Neutrophil cytosolic factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | 0.999 |
Cyba | Ncf4 | ENSRNOP00000017564 | ENSRNOP00000009544 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | 0.997 |
Cyba | Nox1 | ENSRNOP00000017564 | ENSRNOP00000065995 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. | 0.999 |
Cyba | Nox3 | ENSRNOP00000017564 | ENSRNOP00000022148 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). | 0.998 |
Cyba | Nox4 | ENSRNOP00000017564 | ENSRNOP00000018990 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. | 0.999 |
Cyba | Rac1 | ENSRNOP00000017564 | ENSRNOP00000001417 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.970 |
Cyba | Rac2 | ENSRNOP00000017564 | ENSRNOP00000009994 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). | 0.999 |
Cyba | Vcam1 | ENSRNOP00000017564 | ENSRNOP00000071423 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. | 0.950 |
Cybb | Cyba | ENSRNOP00000031063 | ENSRNOP00000017564 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. | 0.999 |
Cybb | Duox1 | ENSRNOP00000031063 | ENSRNOP00000045928 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. | 0.969 |
Cybb | Ncf1 | ENSRNOP00000031063 | ENSRNOP00000002028 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Neutrophil cytosolic factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). | 0.999 |
Cybb | Ncf4 | ENSRNOP00000031063 | ENSRNOP00000009544 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Similar to neutrophil cytosolic factor 4, isoform CRA_a. | 0.996 |
Cybb | Nox1 | ENSRNOP00000031063 | ENSRNOP00000065995 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. | 0.998 |
Cybb | Nox3 | ENSRNOP00000031063 | ENSRNOP00000022148 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity). | 0.993 |
Cybb | Nox4 | ENSRNOP00000031063 | ENSRNOP00000018990 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. | 0.998 |
Cybb | Rac1 | ENSRNOP00000031063 | ENSRNOP00000001417 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.968 |
Cybb | Rac2 | ENSRNOP00000031063 | ENSRNOP00000009994 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). | 0.999 |
Cybb | Vcam1 | ENSRNOP00000031063 | ENSRNOP00000071423 | Cytochrome b-245, beta polypeptide, isoform CRA_a. | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. | 0.967 |