STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rab5cRAB5C, member RAS oncogene family (216 aa)    
Predicted Functional Partners:
Rabgef1
Rab guanine nucleotide exchange factor (gef) 1 (predicted), isoform cra_a; RAB guanine nucleotide exchange factor (GEF) 1
   
 0.988
Eea1
Early endosome antigen 1
   
 0.984
Rin2
Ras and rab interactor 2 (predicted), isoform cra_c; Ras and Rab interactor 2
   
 0.981
Rin1
annotation not available
    
 0.968
Als2
ALS2, alsin Rho guanine nucleotide exchange factor; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons
   
 0.954
Rinl
Similar to RIKEN cDNA 5830482F20 gene (Predicted); Ras and Rab interactor-like
    
 0.947
Gdi1
Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes
   
 0.943
Snx2
Sorting nexin-1/2; Sorting nexin 2
   
 0.942
Pik3c3
Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...]
   
 0.938
ENSRNOP00000027335
Ras and Rab interactor 1-like
    
 0.937
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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