node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1c1 | Akr1c3 | ENSRNOP00000055169 | ENSRNOP00000023739 | Type 5 17beta-hydroxysteroid dehydrogenase. | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 0.907 |
Akr1c1 | Cyp17a1 | ENSRNOP00000055169 | ENSRNOP00000027160 | Type 5 17beta-hydroxysteroid dehydrogenase. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.953 |
Akr1c1 | Hsd17b6-2 | ENSRNOP00000055169 | ENSRNOP00000031599 | Type 5 17beta-hydroxysteroid dehydrogenase. | Hydroxysteroid 17-beta dehydrogenase 6-like. | 0.470 |
Akr1c1 | Hsd3b2 | ENSRNOP00000055169 | ENSRNOP00000026306 | Type 5 17beta-hydroxysteroid dehydrogenase. | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.948 |
Akr1c1 | Hsd3b5 | ENSRNOP00000055169 | ENSRNOP00000072555 | Type 5 17beta-hydroxysteroid dehydrogenase. | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. | 0.929 |
Akr1c1 | RGD1564865 | ENSRNOP00000055169 | ENSRNOP00000055214 | Type 5 17beta-hydroxysteroid dehydrogenase. | Similar to 20-alpha-hydroxysteroid dehydrogenase. | 0.579 |
Akr1c1 | Srd5a1 | ENSRNOP00000055169 | ENSRNOP00000023659 | Type 5 17beta-hydroxysteroid dehydrogenase. | 3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.962 |
Akr1c1 | UST4r | ENSRNOP00000055169 | ENSRNOP00000047683 | Type 5 17beta-hydroxysteroid dehydrogenase. | Integral membrane transport protein UST4r. | 0.514 |
Akr1c3 | Akr1c1 | ENSRNOP00000023739 | ENSRNOP00000055169 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Type 5 17beta-hydroxysteroid dehydrogenase. | 0.907 |
Akr1c3 | Cyp17a1 | ENSRNOP00000023739 | ENSRNOP00000027160 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.957 |
Akr1c3 | Hsd17b6-2 | ENSRNOP00000023739 | ENSRNOP00000031599 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Hydroxysteroid 17-beta dehydrogenase 6-like. | 0.462 |
Akr1c3 | Hsd3b2 | ENSRNOP00000023739 | ENSRNOP00000026306 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.965 |
Akr1c3 | Hsd3b5 | ENSRNOP00000023739 | ENSRNOP00000072555 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase; Belongs to the 3-beta-HSD family. | 0.943 |
Akr1c3 | RGD1564865 | ENSRNOP00000023739 | ENSRNOP00000055214 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | Similar to 20-alpha-hydroxysteroid dehydrogenase. | 0.411 |
Akr1c3 | Srd5a1 | ENSRNOP00000023739 | ENSRNOP00000023659 | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.970 |
Cyp17a1 | Akr1c1 | ENSRNOP00000027160 | ENSRNOP00000055169 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Type 5 17beta-hydroxysteroid dehydrogenase. | 0.953 |
Cyp17a1 | Akr1c3 | ENSRNOP00000027160 | ENSRNOP00000023739 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP). | 0.957 |
Cyp17a1 | Hsd17b6-2 | ENSRNOP00000027160 | ENSRNOP00000031599 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Hydroxysteroid 17-beta dehydrogenase 6-like. | 0.539 |
Cyp17a1 | Hsd17b8 | ENSRNOP00000027160 | ENSRNOP00000000542 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.936 |
Cyp17a1 | Hsd3b2 | ENSRNOP00000027160 | ENSRNOP00000026306 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. | 0.993 |