node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cop1 | Stk40 | ENSRNOP00000048511 | ENSRNOP00000032827 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.718 |
Cop1 | Trib1 | ENSRNOP00000048511 | ENSRNOP00000005885 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Tribbles homolog 1 (Drosophila). | 0.770 |
Cop1 | Trib3 | ENSRNOP00000048511 | ENSRNOP00000009840 | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr- 308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activi [...] | 0.854 |
Ctc1 | Dnajb4 | ENSRNOP00000007447 | ENSRNOP00000075386 | Similar to novel protein (Predicted), isoform CRA_b. | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | 0.604 |
Ctc1 | Stk40 | ENSRNOP00000007447 | ENSRNOP00000032827 | Similar to novel protein (Predicted), isoform CRA_b. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.625 |
Ctc1 | Vac14 | ENSRNOP00000007447 | ENSRNOP00000023383 | Similar to novel protein (Predicted), isoform CRA_b. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity); Belongs to the VAC14 family. | 0.635 |
Ctc1 | Yars1 | ENSRNOP00000007447 | ENSRNOP00000010674 | Similar to novel protein (Predicted), isoform CRA_b. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.695 |
Dnajb4 | Ctc1 | ENSRNOP00000075386 | ENSRNOP00000007447 | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | Similar to novel protein (Predicted), isoform CRA_b. | 0.604 |
Dnajb4 | Stk40 | ENSRNOP00000075386 | ENSRNOP00000032827 | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.642 |
Dnajb4 | Vac14 | ENSRNOP00000075386 | ENSRNOP00000023383 | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity); Belongs to the VAC14 family. | 0.619 |
Dnajb4 | Yars1 | ENSRNOP00000075386 | ENSRNOP00000010674 | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.594 |
Pdik1l | Stk40 | ENSRNOP00000022141 | ENSRNOP00000032827 | PDLIM1 interacting kinase 1 like (Predicted); Belongs to the protein kinase superfamily. | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.594 |
Ppp6c | Stk40 | ENSRNOP00000021176 | ENSRNOP00000032827 | Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential [...] | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.633 |
Stk40 | Cop1 | ENSRNOP00000032827 | ENSRNOP00000048511 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Similar to constitutive photomorphogenic protein 1, isoform CRA_b. | 0.718 |
Stk40 | Ctc1 | ENSRNOP00000032827 | ENSRNOP00000007447 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Similar to novel protein (Predicted), isoform CRA_b. | 0.625 |
Stk40 | Dnajb4 | ENSRNOP00000032827 | ENSRNOP00000075386 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | DnaJ (Hsp40) homolog, subfamily B, member 4, isoform CRA_a. | 0.642 |
Stk40 | Pdik1l | ENSRNOP00000032827 | ENSRNOP00000022141 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | PDLIM1 interacting kinase 1 like (Predicted); Belongs to the protein kinase superfamily. | 0.594 |
Stk40 | Ppp6c | ENSRNOP00000032827 | ENSRNOP00000021176 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential [...] | 0.633 |
Stk40 | Strada | ENSRNOP00000032827 | ENSRNOP00000051998 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. | 0.657 |
Stk40 | Trib1 | ENSRNOP00000032827 | ENSRNOP00000005885 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Tribbles homolog 1 (Drosophila). | 0.709 |