node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adh7 | Cyp26a1 | ENSRNOP00000015870 | ENSRNOP00000022549 | All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency [...] | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.933 |
Adh7 | Pnpla4 | ENSRNOP00000015870 | ENSRNOP00000033754 | All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency [...] | Patatin-like phospholipase domain-containing 4. | 0.901 |
Adh7 | Retsat | ENSRNOP00000015870 | ENSRNOP00000019571 | All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency [...] | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.915 |
Cyp26a1 | Adh7 | ENSRNOP00000022549 | ENSRNOP00000015870 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency [...] | 0.933 |
Cyp26a1 | Dhrs4 | ENSRNOP00000022549 | ENSRNOP00000024782 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.935 |
Cyp26a1 | Dhrs9 | ENSRNOP00000022549 | ENSRNOP00000069708 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.956 |
Cyp26a1 | Hsd17b6 | ENSRNOP00000022549 | ENSRNOP00000003498 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) (By similarity). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17- beta-diol to androsterone and estradiol to estrone (in vitro). Has 3- alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.904 |
Cyp26a1 | Pnpla4 | ENSRNOP00000022549 | ENSRNOP00000033754 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Patatin-like phospholipase domain-containing 4. | 0.901 |
Cyp26a1 | Rdh12 | ENSRNOP00000022549 | ENSRNOP00000074812 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 12 (Predicted); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.951 |
Cyp26a1 | Rdh16 | ENSRNOP00000022549 | ENSRNOP00000039311 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol (By similarity). Oxidizes 3- alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.942 |
Cyp26a1 | Rdh7 | ENSRNOP00000022549 | ENSRNOP00000005875 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.931 |
Cyp26a1 | Retsat | ENSRNOP00000022549 | ENSRNOP00000019571 | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.930 |
Dhrs4 | Cyp26a1 | ENSRNOP00000024782 | ENSRNOP00000022549 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.935 |
Dhrs4 | Dhrs9 | ENSRNOP00000024782 | ENSRNOP00000069708 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.948 |
Dhrs4 | Pnpla4 | ENSRNOP00000024782 | ENSRNOP00000033754 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Patatin-like phospholipase domain-containing 4. | 0.906 |
Dhrs4 | Rdh16 | ENSRNOP00000024782 | ENSRNOP00000039311 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol (By similarity). Oxidizes 3- alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.416 |
Dhrs4 | Rdh7 | ENSRNOP00000024782 | ENSRNOP00000005875 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.460 |
Dhrs4 | Retsat | ENSRNOP00000024782 | ENSRNOP00000019571 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. | 0.949 |
Dhrs9 | Cyp26a1 | ENSRNOP00000069708 | ENSRNOP00000022549 | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. | 0.956 |
Dhrs9 | Dhrs4 | ENSRNOP00000069708 | ENSRNOP00000024782 | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | 0.948 |