node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fpgs | Gch1 | ENSRNOP00000064076 | ENSRNOP00000014821 | Folylpolyglutamate synthase. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.837 |
Fpgs | Nadsyn1 | ENSRNOP00000064076 | ENSRNOP00000028175 | Folylpolyglutamate synthase. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.586 |
Fpgs | Nudt15 | ENSRNOP00000064076 | ENSRNOP00000072456 | Folylpolyglutamate synthase. | Nudix (Nucleoside diphosphate linked moiety X)-type motif 15 (Predicted); Belongs to the Nudix hydrolase family. | 0.851 |
Fpgs | Tyms | ENSRNOP00000064076 | ENSRNOP00000053086 | Folylpolyglutamate synthase. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.987 |
Gch1 | Fpgs | ENSRNOP00000014821 | ENSRNOP00000064076 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Folylpolyglutamate synthase. | 0.837 |
Gch1 | Nadsyn1 | ENSRNOP00000014821 | ENSRNOP00000028175 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.580 |
Gch1 | Nudt15 | ENSRNOP00000014821 | ENSRNOP00000072456 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Nudix (Nucleoside diphosphate linked moiety X)-type motif 15 (Predicted); Belongs to the Nudix hydrolase family. | 0.899 |
Gch1 | Nudt2 | ENSRNOP00000014821 | ENSRNOP00000017712 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis (By similarity). | 0.870 |
Gch1 | Nudt5 | ENSRNOP00000014821 | ENSRNOP00000023893 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] | 0.406 |
Gch1 | Qprt | ENSRNOP00000014821 | ENSRNOP00000023080 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.488 |
Gch1 | Tyms | ENSRNOP00000014821 | ENSRNOP00000053086 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.571 |
Nadsyn1 | Fpgs | ENSRNOP00000028175 | ENSRNOP00000064076 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Folylpolyglutamate synthase. | 0.586 |
Nadsyn1 | Gch1 | ENSRNOP00000028175 | ENSRNOP00000014821 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family. | 0.580 |
Nadsyn1 | Nudt12 | ENSRNOP00000028175 | ENSRNOP00000061974 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | 0.982 |
Nadsyn1 | Nudt15 | ENSRNOP00000028175 | ENSRNOP00000072456 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Nudix (Nucleoside diphosphate linked moiety X)-type motif 15 (Predicted); Belongs to the Nudix hydrolase family. | 0.911 |
Nadsyn1 | Qprt | ENSRNOP00000028175 | ENSRNOP00000023080 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.946 |
Nudt12 | Nadsyn1 | ENSRNOP00000061974 | ENSRNOP00000028175 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.982 |
Nudt12 | Nudt14 | ENSRNOP00000061974 | ENSRNOP00000019550 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | Nudix (Nucleoside diphosphate linked moiety X)-type motif 14 (Predicted). | 0.841 |
Nudt12 | Nudt15 | ENSRNOP00000061974 | ENSRNOP00000072456 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | Nudix (Nucleoside diphosphate linked moiety X)-type motif 15 (Predicted); Belongs to the Nudix hydrolase family. | 0.818 |
Nudt12 | Nudt18 | ENSRNOP00000061974 | ENSRNOP00000015969 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | 8-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity). | 0.809 |