node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alg8 | Canx | ENSRNOP00000016478 | ENSRNOP00000040859 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | 0.511 |
Alg8 | Dnajb11 | ENSRNOP00000016478 | ENSRNOP00000002462 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | 0.514 |
Alg8 | Ganab | ENSRNOP00000016478 | ENSRNOP00000036123 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | Alpha glucosidase 2 alpha neutral subunit (Predicted); Belongs to the glycosyl hydrolase 31 family. | 0.839 |
Alg8 | LOC103692171 | ENSRNOP00000016478 | ENSRNOP00000074720 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.615 |
Alg8 | Prkcsh | ENSRNOP00000016478 | ENSRNOP00000018009 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | Protein kinase C substrate 80K-H (Predicted), isoform CRA_b. | 0.709 |
Alg8 | Uggt1 | ENSRNOP00000016478 | ENSRNOP00000020558 | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. | 0.456 |
Canx | Alg8 | ENSRNOP00000040859 | ENSRNOP00000016478 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | 0.511 |
Canx | Dnajb11 | ENSRNOP00000040859 | ENSRNOP00000002462 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | 0.499 |
Canx | Ganab | ENSRNOP00000040859 | ENSRNOP00000036123 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Alpha glucosidase 2 alpha neutral subunit (Predicted); Belongs to the glycosyl hydrolase 31 family. | 0.859 |
Canx | LOC103692171 | ENSRNOP00000040859 | ENSRNOP00000074720 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.650 |
Canx | Man1b1 | ENSRNOP00000040859 | ENSRNOP00000016846 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity); Belongs to the glycosyl hydrolase 47 family. | 0.528 |
Canx | Pdia3 | ENSRNOP00000040859 | ENSRNOP00000020478 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Protein disulfide-isomerase A3. | 0.999 |
Canx | Prkcsh | ENSRNOP00000040859 | ENSRNOP00000018009 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | Protein kinase C substrate 80K-H (Predicted), isoform CRA_b. | 0.520 |
Canx | Uggt1 | ENSRNOP00000040859 | ENSRNOP00000020558 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] | UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. | 0.938 |
Clgn | Ganab | ENSRNOP00000005071 | ENSRNOP00000036123 | Calmegin. | Alpha glucosidase 2 alpha neutral subunit (Predicted); Belongs to the glycosyl hydrolase 31 family. | 0.809 |
Clgn | LOC103692171 | ENSRNOP00000005071 | ENSRNOP00000074720 | Calmegin. | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.650 |
Clgn | Man1b1 | ENSRNOP00000005071 | ENSRNOP00000016846 | Calmegin. | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity); Belongs to the glycosyl hydrolase 47 family. | 0.400 |
Clgn | Pdia3 | ENSRNOP00000005071 | ENSRNOP00000020478 | Calmegin. | Protein disulfide-isomerase A3. | 0.650 |
Clgn | Uggt1 | ENSRNOP00000005071 | ENSRNOP00000020558 | Calmegin. | UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. | 0.689 |
Dnajb11 | Alg8 | ENSRNOP00000002462 | ENSRNOP00000016478 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family. | 0.514 |