STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Upk1aCytochrome c oxidase, subunit VIb (Predicted); Belongs to the tetraspanin (TM4SF) family. (207 aa)    
Predicted Functional Partners:
Upk2
Uroplakin 2.
  
 
 0.985
Upk3a
Uroplakin 3A (Predicted).
   
 
 0.910
Upk1b
Uroplakin-1b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity); Belongs to the tetraspanin (TM4SF) family.
  
  
0.849
Upk3b
Uroplakin 3B.
   
  
 0.826
Krt20
Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
   
  
 0.628
Tspan31
Tetraspanin-31.
      
 0.565
Krt13
Keratin, type I cytoskeletal 13.
   
  
 0.514
Cd37
Leukocyte antigen CD37.
      
 0.443
Tmed11
Transmembrane emp24 protein transport domain-containing 11.
      
 0.440
Tspan11
Tetraspanin-11.
      
 0.435
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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