node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd22 | Trafd1 | ENSRNOP00000026093 | ENSRNOP00000072077 | Ankyrin repeat domain 22. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.457 |
Atp6ap1 | Trafd1 | ENSRNOP00000069530 | ENSRNOP00000072077 | V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)- ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering th [...] | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.471 |
Ifi47 | Lgals3bp | ENSRNOP00000003343 | ENSRNOP00000004320 | Interferon gamma-inducible protein 47. | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). | 0.498 |
Ifi47 | Mx2 | ENSRNOP00000003343 | ENSRNOP00000002695 | Interferon gamma-inducible protein 47. | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | 0.557 |
Ifi47 | Tapbp | ENSRNOP00000003343 | ENSRNOP00000045630 | Interferon gamma-inducible protein 47. | Tap-binding protein (Tapasin). | 0.494 |
Ifi47 | Trafd1 | ENSRNOP00000003343 | ENSRNOP00000072077 | Interferon gamma-inducible protein 47. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.521 |
Ifrd1 | Trafd1 | ENSRNOP00000067730 | ENSRNOP00000072077 | Interferon-related developmental regulator 1; Probably participates in neurogenesis. Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF; Belongs to the IFRD family. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.489 |
Lgals3bp | Ifi47 | ENSRNOP00000004320 | ENSRNOP00000003343 | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). | Interferon gamma-inducible protein 47. | 0.498 |
Lgals3bp | Mx2 | ENSRNOP00000004320 | ENSRNOP00000002695 | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | 0.460 |
Lgals3bp | Trafd1 | ENSRNOP00000004320 | ENSRNOP00000072077 | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.599 |
Mx2 | Ifi47 | ENSRNOP00000002695 | ENSRNOP00000003343 | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | Interferon gamma-inducible protein 47. | 0.557 |
Mx2 | Lgals3bp | ENSRNOP00000002695 | ENSRNOP00000004320 | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). | 0.460 |
Mx2 | Trafd1 | ENSRNOP00000002695 | ENSRNOP00000072077 | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.557 |
Psme1 | Tapbp | ENSRNOP00000025887 | ENSRNOP00000045630 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. | Tap-binding protein (Tapasin). | 0.657 |
Psme1 | Trafd1 | ENSRNOP00000025887 | ENSRNOP00000072077 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.602 |
Snx10 | Trafd1 | ENSRNOP00000016265 | ENSRNOP00000072077 | Sorting nexin 10, isoform CRA_b. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.472 |
Tapbp | Ifi47 | ENSRNOP00000045630 | ENSRNOP00000003343 | Tap-binding protein (Tapasin). | Interferon gamma-inducible protein 47. | 0.494 |
Tapbp | Psme1 | ENSRNOP00000045630 | ENSRNOP00000025887 | Tap-binding protein (Tapasin). | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. | 0.657 |
Tapbp | Trafd1 | ENSRNOP00000045630 | ENSRNOP00000072077 | Tap-binding protein (Tapasin). | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.452 |
Tmem116 | Trafd1 | ENSRNOP00000063208 | ENSRNOP00000072077 | Transmembrane protein 116. | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). | 0.560 |