node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dgkh | Inpp5a | ENSRNOP00000054887 | ENSRNOP00000051774 | Diacylglycerol kinase. | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | 0.479 |
Dgkh | Mtmr12 | ENSRNOP00000054887 | ENSRNOP00000036677 | Diacylglycerol kinase. | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.442 |
Golph3 | Mtmr12 | ENSRNOP00000017276 | ENSRNOP00000036677 | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.449 |
Inpp5a | Dgkh | ENSRNOP00000051774 | ENSRNOP00000054887 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Diacylglycerol kinase. | 0.479 |
Inpp5a | Mtmr12 | ENSRNOP00000051774 | ENSRNOP00000036677 | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.487 |
Lrguk | Mtmr12 | ENSRNOP00000011692 | ENSRNOP00000036677 | Leucine-rich repeats and guanylate kinase domain-containing. | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.539 |
Mtm1 | Mtmr12 | ENSRNOP00000058761 | ENSRNOP00000036677 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.922 |
Mtm1 | Mtmr14 | ENSRNOP00000058761 | ENSRNOP00000010723 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] | Similar to FLJ22405 protein (Predicted). | 0.802 |
Mtmr12 | Dgkh | ENSRNOP00000036677 | ENSRNOP00000054887 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Diacylglycerol kinase. | 0.442 |
Mtmr12 | Golph3 | ENSRNOP00000036677 | ENSRNOP00000017276 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] | 0.449 |
Mtmr12 | Inpp5a | ENSRNOP00000036677 | ENSRNOP00000051774 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Inositol polyphosphate-5-phosphatase A (Predicted), isoform CRA_a. | 0.487 |
Mtmr12 | Lrguk | ENSRNOP00000036677 | ENSRNOP00000011692 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Leucine-rich repeats and guanylate kinase domain-containing. | 0.539 |
Mtmr12 | Mtm1 | ENSRNOP00000036677 | ENSRNOP00000058761 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] | 0.922 |
Mtmr12 | Mtmr14 | ENSRNOP00000036677 | ENSRNOP00000010723 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Similar to FLJ22405 protein (Predicted). | 0.497 |
Mtmr12 | Mtmr2 | ENSRNOP00000036677 | ENSRNOP00000008566 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Myotubularin related protein 2 (Predicted), isoform CRA_b. | 0.961 |
Mtmr12 | Myo7b | ENSRNOP00000036677 | ENSRNOP00000021405 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Myosin VIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.577 |
Mtmr12 | Vstm5 | ENSRNOP00000036677 | ENSRNOP00000013927 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | V-set and transmembrane domain-containing protein 5; Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical [...] | 0.661 |
Mtmr12 | Zfr | ENSRNOP00000036677 | ENSRNOP00000016196 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Zinc finger RNA-binding protein; Involved in postimplantation and gastrulation stages of development (By similarity). Binds to DNA and RNA (By similarity). Involved in the nucleocytoplasmic shuttling of STAU2. | 0.445 |
Mtmr14 | Mtm1 | ENSRNOP00000010723 | ENSRNOP00000058761 | Similar to FLJ22405 protein (Predicted). | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] | 0.802 |
Mtmr14 | Mtmr12 | ENSRNOP00000010723 | ENSRNOP00000036677 | Similar to FLJ22405 protein (Predicted). | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.497 |