node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aars | Eprs | ENSRNOP00000075266 | ENSRNOP00000071057 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Glutamyl-prolyl-tRNA synthetase. | 0.937 |
Aars | Gars | ENSRNOP00000075266 | ENSRNOP00000014780 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.909 |
Aars | Kars | ENSRNOP00000075266 | ENSRNOP00000044454 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (By similarity). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | 0.888 |
Aars | Lars2 | ENSRNOP00000075266 | ENSRNOP00000074967 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.860 |
Aars | Mars2 | ENSRNOP00000075266 | ENSRNOP00000067312 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Methionine--tRNA ligase, mitochondrial-like; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.786 |
Aars | Pars2 | ENSRNOP00000075266 | ENSRNOP00000054281 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Probable proline--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.796 |
Aars | Wars1 | ENSRNOP00000075266 | ENSRNOP00000006128 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). | 0.859 |
Aars | Wars2 | ENSRNOP00000075266 | ENSRNOP00000026458 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Tryptophanyl tRNA synthetase 2 (mitochondrial); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.740 |
Aars | Yars1 | ENSRNOP00000075266 | ENSRNOP00000010674 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.975 |
Aars | Yars2 | ENSRNOP00000075266 | ENSRNOP00000037398 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | Tyrosine--tRNA ligase, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.875 |
Eprs | Aars | ENSRNOP00000071057 | ENSRNOP00000075266 | Glutamyl-prolyl-tRNA synthetase. | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. | 0.937 |
Eprs | Gars | ENSRNOP00000071057 | ENSRNOP00000014780 | Glutamyl-prolyl-tRNA synthetase. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.960 |
Eprs | Kars | ENSRNOP00000071057 | ENSRNOP00000044454 | Glutamyl-prolyl-tRNA synthetase. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (By similarity). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | 0.999 |
Eprs | Lars2 | ENSRNOP00000071057 | ENSRNOP00000074967 | Glutamyl-prolyl-tRNA synthetase. | Leucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.978 |
Eprs | Mars2 | ENSRNOP00000071057 | ENSRNOP00000067312 | Glutamyl-prolyl-tRNA synthetase. | Methionine--tRNA ligase, mitochondrial-like; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.974 |
Eprs | Pars2 | ENSRNOP00000071057 | ENSRNOP00000054281 | Glutamyl-prolyl-tRNA synthetase. | Probable proline--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.986 |
Eprs | Wars1 | ENSRNOP00000071057 | ENSRNOP00000006128 | Glutamyl-prolyl-tRNA synthetase. | Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). | 0.847 |
Eprs | Wars2 | ENSRNOP00000071057 | ENSRNOP00000026458 | Glutamyl-prolyl-tRNA synthetase. | Tryptophanyl tRNA synthetase 2 (mitochondrial); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.870 |
Eprs | Yars1 | ENSRNOP00000071057 | ENSRNOP00000010674 | Glutamyl-prolyl-tRNA synthetase. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.999 |
Eprs | Yars2 | ENSRNOP00000071057 | ENSRNOP00000037398 | Glutamyl-prolyl-tRNA synthetase. | Tyrosine--tRNA ligase, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.949 |