STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arhgef37Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). (676 aa)    
Predicted Functional Partners:
Fchsd1
FCH and double SH3 domains 1 (Predicted), isoform CRA_b.
    
 
 0.710
Arhgap42
Rho GTPase-activating protein 42.
      
 0.699
Mtss2
MTSS I-BAR domain-containing 2.
   
 
 0.686
Arhgap44
Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contract [...]
      
 0.667
Arhgap45
Histocompatibility (Minor) HA-1 (Predicted), isoform CRA_b.
    
 
 0.655
Arhgap4
Rho GTPase activating protein 4, isoform CRA_a.
    
 
 0.647
Bin3
Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin.
    
 
 0.624
Bin2
Bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation (By similarity). Plays a role in podosome formation. Inhibits phagocytosis.
    
 
 0.608
Arhgef40
Rho guanine nucleotide exchange factor 40.
    
 
 0.608
Mtss1
Metastasis suppressor 1 (Predicted), isoform CRA_a.
   
 
 0.578
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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