node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brd3 | Gata1 | ENSRNOP00000073373 | ENSRNOP00000038111 | Bromodomain containing 3 (Predicted), isoform CRA_a. | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | 0.928 |
Gata1 | Brd3 | ENSRNOP00000038111 | ENSRNOP00000073373 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Bromodomain containing 3 (Predicted), isoform CRA_a. | 0.928 |
Gata1 | Gfi1b | ENSRNOP00000038111 | ENSRNOP00000070622 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Growth factor-independent 1B transcriptional repressor. | 0.908 |
Gata1 | Klf1 | ENSRNOP00000038111 | ENSRNOP00000004601 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Kruppel-like factor 1 (Erythroid) (Predicted). | 0.933 |
Gata1 | Ldb1 | ENSRNOP00000038111 | ENSRNOP00000069575 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | LIM domain-binding 1. | 0.996 |
Gata1 | Lmo2 | ENSRNOP00000038111 | ENSRNOP00000012625 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | LIM domain only 2. | 0.998 |
Gata1 | Runx1 | ENSRNOP00000038111 | ENSRNOP00000070750 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Runt-related transcription factor 1; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy [...] | 0.959 |
Gata1 | Spi1 | ENSRNOP00000038111 | ENSRNOP00000016306 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.922 |
Gata1 | Tal1 | ENSRNOP00000038111 | ENSRNOP00000071897 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | TAL bHLH transcription factor 1, erythroid differentiation factor. | 0.998 |
Gata1 | Tcf3 | ENSRNOP00000038111 | ENSRNOP00000071280 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B- cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs. | 0.884 |
Gata1 | Zfpm1 | ENSRNOP00000038111 | ENSRNOP00000061082 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | Zinc finger protein, multitype 1. | 0.992 |
Gfi1b | Gata1 | ENSRNOP00000070622 | ENSRNOP00000038111 | Growth factor-independent 1B transcriptional repressor. | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | 0.908 |
Gfi1b | Klf1 | ENSRNOP00000070622 | ENSRNOP00000004601 | Growth factor-independent 1B transcriptional repressor. | Kruppel-like factor 1 (Erythroid) (Predicted). | 0.562 |
Gfi1b | Ldb1 | ENSRNOP00000070622 | ENSRNOP00000069575 | Growth factor-independent 1B transcriptional repressor. | LIM domain-binding 1. | 0.645 |
Gfi1b | Lmo2 | ENSRNOP00000070622 | ENSRNOP00000012625 | Growth factor-independent 1B transcriptional repressor. | LIM domain only 2. | 0.841 |
Gfi1b | Runx1 | ENSRNOP00000070622 | ENSRNOP00000070750 | Growth factor-independent 1B transcriptional repressor. | Runt-related transcription factor 1; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy [...] | 0.594 |
Gfi1b | Spi1 | ENSRNOP00000070622 | ENSRNOP00000016306 | Growth factor-independent 1B transcriptional repressor. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). | 0.613 |
Gfi1b | Tal1 | ENSRNOP00000070622 | ENSRNOP00000071897 | Growth factor-independent 1B transcriptional repressor. | TAL bHLH transcription factor 1, erythroid differentiation factor. | 0.797 |
Gfi1b | Zfpm1 | ENSRNOP00000070622 | ENSRNOP00000061082 | Growth factor-independent 1B transcriptional repressor. | Zinc finger protein, multitype 1. | 0.501 |
Klf1 | Gata1 | ENSRNOP00000004601 | ENSRNOP00000038111 | Kruppel-like factor 1 (Erythroid) (Predicted). | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. | 0.933 |