node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dhrs11 | Ggnbp2 | ENSRNOP00000038582 | ENSRNOP00000073773 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | 0.776 |
Dhrs11 | Hsd17b1 | ENSRNOP00000038582 | ENSRNOP00000026878 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.968 |
Dhrs11 | Hsd17b12 | ENSRNOP00000038582 | ENSRNOP00000012806 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] | 0.931 |
Dhrs11 | Hsd17b2 | ENSRNOP00000038582 | ENSRNOP00000018795 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.970 |
Dhrs11 | Hsd17b6 | ENSRNOP00000038582 | ENSRNOP00000003498 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) (By similarity). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17- beta-diol to androsterone and estradiol to estrone (in vitro). Has 3- alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.923 |
Dhrs11 | Hsd17b7 | ENSRNOP00000038582 | ENSRNOP00000003812 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. | 0.956 |
Dhrs11 | Hsd17b8 | ENSRNOP00000038582 | ENSRNOP00000000542 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.923 |
Dhrs11 | Mrm1 | ENSRNOP00000038582 | ENSRNOP00000034375 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Mitochondrial rRNA methyltransferase 1. | 0.776 |
Dhrs11 | Pigw | ENSRNOP00000038582 | ENSRNOP00000060195 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Phosphatidylinositol-glycan biosynthesis class W protein; Required for the transport of GPI-anchored proteins to the plasma membrane (By similarity). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. | 0.807 |
Dhrs11 | Znhit3 | ENSRNOP00000038582 | ENSRNOP00000033107 | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Similar to thyroid hormone receptor interactor 3, isoform CRA_d. | 0.778 |
Ggnbp2 | Dhrs11 | ENSRNOP00000073773 | ENSRNOP00000038582 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.776 |
Ggnbp2 | Hsd17b12 | ENSRNOP00000073773 | ENSRNOP00000012806 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] | 0.490 |
Ggnbp2 | Mrm1 | ENSRNOP00000073773 | ENSRNOP00000034375 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Mitochondrial rRNA methyltransferase 1. | 0.701 |
Ggnbp2 | Pigw | ENSRNOP00000073773 | ENSRNOP00000060195 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Phosphatidylinositol-glycan biosynthesis class W protein; Required for the transport of GPI-anchored proteins to the plasma membrane (By similarity). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. | 0.671 |
Ggnbp2 | Znhit3 | ENSRNOP00000073773 | ENSRNOP00000033107 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Similar to thyroid hormone receptor interactor 3, isoform CRA_d. | 0.733 |
Hsd17b1 | Dhrs11 | ENSRNOP00000026878 | ENSRNOP00000038582 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dehydrogenase/reductase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.968 |
Hsd17b1 | Hsd17b12 | ENSRNOP00000026878 | ENSRNOP00000012806 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] | 0.961 |
Hsd17b1 | Hsd17b2 | ENSRNOP00000026878 | ENSRNOP00000018795 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.973 |
Hsd17b1 | Hsd17b6 | ENSRNOP00000026878 | ENSRNOP00000003498 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) (By similarity). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17- beta-diol to androsterone and estradiol to estrone (in vitro). Has 3- alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.933 |
Hsd17b1 | Hsd17b7 | ENSRNOP00000026878 | ENSRNOP00000003812 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. | 0.969 |