node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fgf14 | Gpr158 | ENSRNOP00000042838 | ENSRNOP00000038884 | Fibroblast growth factor 14; Probably involved in nervous system development and function. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.617 |
Gnb5 | Gpr158 | ENSRNOP00000011963 | ENSRNOP00000038884 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.778 |
Gnb5 | Rgs6 | ENSRNOP00000011963 | ENSRNOP00000069089 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | Regulator of G-protein-signaling 6. | 0.994 |
Gnb5 | Rgs7 | ENSRNOP00000011963 | ENSRNOP00000063631 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. | 0.999 |
Gnb5 | Rgs9 | ENSRNOP00000011963 | ENSRNOP00000005076 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | Regulator of G-protein signaling 9; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). | 0.991 |
Gpc4 | Gpr158 | ENSRNOP00000003282 | ENSRNOP00000038884 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.632 |
Gpr137 | Gpr152 | ENSRNOP00000028707 | ENSRNOP00000051734 | G protein-coupled receptor 137. | G protein-coupled receptor 152; Belongs to the G-protein coupled receptor 1 family. | 0.545 |
Gpr137 | Gpr158 | ENSRNOP00000028707 | ENSRNOP00000038884 | G protein-coupled receptor 137. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.670 |
Gpr152 | Gpr137 | ENSRNOP00000051734 | ENSRNOP00000028707 | G protein-coupled receptor 152; Belongs to the G-protein coupled receptor 1 family. | G protein-coupled receptor 137. | 0.545 |
Gpr152 | Gpr158 | ENSRNOP00000051734 | ENSRNOP00000038884 | G protein-coupled receptor 152; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.612 |
Gpr158 | Fgf14 | ENSRNOP00000038884 | ENSRNOP00000042838 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Fibroblast growth factor 14; Probably involved in nervous system development and function. | 0.617 |
Gpr158 | Gnb5 | ENSRNOP00000038884 | ENSRNOP00000011963 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.778 |
Gpr158 | Gpc4 | ENSRNOP00000038884 | ENSRNOP00000003282 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | 0.632 |
Gpr158 | Gpr137 | ENSRNOP00000038884 | ENSRNOP00000028707 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | G protein-coupled receptor 137. | 0.670 |
Gpr158 | Gpr152 | ENSRNOP00000038884 | ENSRNOP00000051734 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | G protein-coupled receptor 152; Belongs to the G-protein coupled receptor 1 family. | 0.612 |
Gpr158 | Gprc5b | ENSRNOP00000038884 | ENSRNOP00000072971 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | G protein-coupled receptor, family C, group 5, member B (Predicted), isoform CRA_b. | 0.662 |
Gpr158 | Gprc6a | ENSRNOP00000038884 | ENSRNOP00000000451 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | G-protein coupled receptor family C group 6 member A; Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, diva [...] | 0.845 |
Gpr158 | Rgs6 | ENSRNOP00000038884 | ENSRNOP00000069089 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Regulator of G-protein-signaling 6. | 0.613 |
Gpr158 | Rgs7 | ENSRNOP00000038884 | ENSRNOP00000063631 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. | 0.950 |
Gpr158 | Rgs9 | ENSRNOP00000038884 | ENSRNOP00000005076 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Regulator of G-protein signaling 9; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). | 0.689 |