node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A0G2K2J2_RAT | Prkn | ENSRNOP00000072264 | ENSRNOP00000075137 | RBR-type E3 ubiquitin transferase. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of mi [...] | 0.714 |
A0A0G2K2J2_RAT | Rps27a | ENSRNOP00000072264 | ENSRNOP00000005872 | RBR-type E3 ubiquitin transferase. | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] | 0.727 |
A0A0G2K2J2_RAT | Uba52 | ENSRNOP00000072264 | ENSRNOP00000027073 | RBR-type E3 ubiquitin transferase. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.773 |
A0A0G2K2J2_RAT | Ubc | ENSRNOP00000072264 | ENSRNOP00000074688 | RBR-type E3 ubiquitin transferase. | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.839 |
A0A0G2K2J2_RAT | Ube2l6 | ENSRNOP00000072264 | ENSRNOP00000039001 | RBR-type E3 ubiquitin transferase. | Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. | 0.892 |
Arih1 | Isg15 | ENSRNOP00000013581 | ENSRNOP00000035405 | RBR-type E3 ubiquitin transferase. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.700 |
Arih1 | Prkn | ENSRNOP00000013581 | ENSRNOP00000075137 | RBR-type E3 ubiquitin transferase. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of mi [...] | 0.504 |
Arih1 | Rps27a | ENSRNOP00000013581 | ENSRNOP00000005872 | RBR-type E3 ubiquitin transferase. | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] | 0.620 |
Arih1 | Trim25 | ENSRNOP00000013581 | ENSRNOP00000052533 | RBR-type E3 ubiquitin transferase. | Tripartite motif-containing 25. | 0.795 |
Arih1 | Uba52 | ENSRNOP00000013581 | ENSRNOP00000027073 | RBR-type E3 ubiquitin transferase. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.771 |
Arih1 | Uba7 | ENSRNOP00000013581 | ENSRNOP00000074046 | RBR-type E3 ubiquitin transferase. | Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. | 0.690 |
Arih1 | Ubc | ENSRNOP00000013581 | ENSRNOP00000074688 | RBR-type E3 ubiquitin transferase. | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.788 |
Arih1 | Ube2l6 | ENSRNOP00000013581 | ENSRNOP00000039001 | RBR-type E3 ubiquitin transferase. | Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. | 0.962 |
Isg15 | Arih1 | ENSRNOP00000035405 | ENSRNOP00000013581 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | RBR-type E3 ubiquitin transferase. | 0.700 |
Isg15 | Rps27a | ENSRNOP00000035405 | ENSRNOP00000005872 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] | 0.692 |
Isg15 | Trim25 | ENSRNOP00000035405 | ENSRNOP00000052533 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | Tripartite motif-containing 25. | 0.845 |
Isg15 | Uba52 | ENSRNOP00000035405 | ENSRNOP00000027073 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.828 |
Isg15 | Uba7 | ENSRNOP00000035405 | ENSRNOP00000074046 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. | 0.994 |
Isg15 | Ubc | ENSRNOP00000035405 | ENSRNOP00000074688 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] | 0.560 |
Isg15 | Ube2l6 | ENSRNOP00000035405 | ENSRNOP00000039001 | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. | 0.984 |