STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Wnk2WNK lysine deficient protein kinase 2. (2063 aa)    
Predicted Functional Partners:
Hmx2
Similar to Hmx2 protein (Predicted), isoform CRA_b.
    
 
 0.579
Bnc1
Basonuclin 1 (Predicted).
      
 0.567
Zfp385a
Zinc finger protein 385A.
   
 
 0.498
Shisa4
Transmembrane protein 58 (Predicted).
   
 
 0.491
Zfyve21
Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta- 1/ITGB1 cell surface expression (By similarity).
      
 0.489
Slc35e3
Solute carrier family 35, member E3.
   
  
 0.470
Snx11
Sorting nexin 11.
    
 
 0.468
Zxdc
ZXD family zinc finger C.
    
 
 0.462
Fgd6
Similar to FYVE, RhoGEF and PH domain containing 6 (Predicted).
    
 
 0.460
Atp13a5
Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
   
 
 0.450
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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