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Rdh16 protein (Rattus norvegicus) - STRING interaction network
"Rdh16" - Retinol dehydrogenase 2 in Rattus norvegicus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Rdh16Retinol dehydrogenase 2; Acts on retinol bound on cellular retinol-binding protein (CRBP). Has higher activity with NADP rather than NAD (317 aa)    
Predicted Functional Partners:
Cyp26a1
Cytochrome P450, family 26, subfamily a, polypeptide 1 (497 aa)
       
  0.936
Lrat
Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11- cis-retinaldehyde which is the chromophore for rhodopsin and the con [...] (231 aa)
     
 
  0.929
Rlbp1
Retinaldehyde binding protein 1 (317 aa)
       
  0.923
Retsat
All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all- trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation; Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily (609 aa)
     
 
  0.909
Bcmo1
Beta,beta-carotene 15,15’-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family (566 aa)
     
 
  0.905
RGD1562200
Similar to GS2 gene (252 aa)
         
  0.900
Aldh1a2
Retinal dehydrogenase 2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently; Belongs to the aldehyde dehydrogenase family (518 aa)
     
 
  0.821
Aox1
Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N- methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species h [...] (1309 aa)
     
 
  0.788
Akr1c14
3-alpha-hydroxysteroid dehydrogenase; Besides being a 3-alpha-hydroxysteroid dehydrogenase, the enzyme can accomplish diverse functions- as quinone reductase, as an aromatic alcohol dehydrogenase, as dihydrodiol dehydrogenase, and as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase; Belongs to the aldo/keto reductase family (322 aa)
     
   
  0.716
Aldh1a1
Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo (By similarity) (501 aa)
     
 
  0.712
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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