node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Capza2 | Hdhd2 | ENSRNOP00000072041 | ENSRNOP00000039553 | F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | 0.667 |
Capza2 | Septin2 | ENSRNOP00000072041 | ENSRNOP00000024261 | F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] | 0.438 |
E2f5 | Hdhd2 | ENSRNOP00000044464 | ENSRNOP00000039553 | Transcription factor E2F5; Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | 0.488 |
Eif3a | Hdhd2 | ENSRNOP00000063484 | ENSRNOP00000039553 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | 0.508 |
Eif3a | Hnrnpr | ENSRNOP00000063484 | ENSRNOP00000015971 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Heterogeneous nuclear ribonucleoprotein R. | 0.411 |
Eif3a | Lsm14b | ENSRNOP00000063484 | ENSRNOP00000071227 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | RCG38480, isoform CRA_a. | 0.439 |
Hdhd2 | Capza2 | ENSRNOP00000039553 | ENSRNOP00000072041 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). | 0.667 |
Hdhd2 | E2f5 | ENSRNOP00000039553 | ENSRNOP00000044464 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Transcription factor E2F5; Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. | 0.488 |
Hdhd2 | Eif3a | ENSRNOP00000039553 | ENSRNOP00000063484 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | 0.508 |
Hdhd2 | Hnrnpr | ENSRNOP00000039553 | ENSRNOP00000015971 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Heterogeneous nuclear ribonucleoprotein R. | 0.593 |
Hdhd2 | Lsm14b | ENSRNOP00000039553 | ENSRNOP00000071227 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | RCG38480, isoform CRA_a. | 0.693 |
Hdhd2 | Ooep | ENSRNOP00000039553 | ENSRNOP00000066293 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Oocyte-expressed protein. | 0.620 |
Hdhd2 | Prkag2 | ENSRNOP00000039553 | ENSRNOP00000062361 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Protein kinase AMP-activated non-catalytic subunit gamma 2. | 0.417 |
Hdhd2 | Psat1 | ENSRNOP00000039553 | ENSRNOP00000074840 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Phosphoserine aminotransferase. | 0.441 |
Hdhd2 | Septin2 | ENSRNOP00000039553 | ENSRNOP00000024261 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] | 0.456 |
Hdhd2 | Ufd1 | ENSRNOP00000039553 | ENSRNOP00000067081 | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] | 0.419 |
Hnrnpr | Eif3a | ENSRNOP00000015971 | ENSRNOP00000063484 | Heterogeneous nuclear ribonucleoprotein R. | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | 0.411 |
Hnrnpr | Hdhd2 | ENSRNOP00000015971 | ENSRNOP00000039553 | Heterogeneous nuclear ribonucleoprotein R. | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | 0.593 |
Lsm14b | Eif3a | ENSRNOP00000071227 | ENSRNOP00000063484 | RCG38480, isoform CRA_a. | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | 0.439 |
Lsm14b | Hdhd2 | ENSRNOP00000071227 | ENSRNOP00000039553 | RCG38480, isoform CRA_a. | Haloacid dehalogenase-like hydrolase domain-containing protein 2. | 0.693 |