node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actn2 | Mybpc3 | ENSRNOP00000024098 | ENSRNOP00000016652 | Actinin alpha 2. | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | 0.853 |
Actn2 | Myh6 | ENSRNOP00000024098 | ENSRNOP00000023301 | Actinin alpha 2. | Myosin-6; Muscle contraction. | 0.908 |
Actn2 | Myh7 | ENSRNOP00000024098 | ENSRNOP00000024186 | Actinin alpha 2. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.865 |
Actn2 | Myl1 | ENSRNOP00000024098 | ENSRNOP00000017838 | Actinin alpha 2. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.843 |
Actn2 | Myl2 | ENSRNOP00000024098 | ENSRNOP00000039707 | Actinin alpha 2. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.891 |
Actn2 | Myl3 | ENSRNOP00000024098 | ENSRNOP00000028458 | Actinin alpha 2. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.856 |
Actn2 | Tnnc1 | ENSRNOP00000024098 | ENSRNOP00000025606 | Actinin alpha 2. | Troponin C1, slow skeletal and cardiac type. | 0.771 |
Actn2 | Tnni1 | ENSRNOP00000024098 | ENSRNOP00000067933 | Actinin alpha 2. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.891 |
Actn2 | Tnni3 | ENSRNOP00000024098 | ENSRNOP00000024640 | Actinin alpha 2. | Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.855 |
Actn2 | Tnnt2 | ENSRNOP00000024098 | ENSRNOP00000069434 | Actinin alpha 2. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.920 |
Mybpc3 | Actn2 | ENSRNOP00000016652 | ENSRNOP00000024098 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Actinin alpha 2. | 0.853 |
Mybpc3 | Myh6 | ENSRNOP00000016652 | ENSRNOP00000023301 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin-6; Muscle contraction. | 0.984 |
Mybpc3 | Myh7 | ENSRNOP00000016652 | ENSRNOP00000024186 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.982 |
Mybpc3 | Myl1 | ENSRNOP00000016652 | ENSRNOP00000017838 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.734 |
Mybpc3 | Myl2 | ENSRNOP00000016652 | ENSRNOP00000039707 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.900 |
Mybpc3 | Myl3 | ENSRNOP00000016652 | ENSRNOP00000028458 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.924 |
Mybpc3 | Tnnc1 | ENSRNOP00000016652 | ENSRNOP00000025606 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Troponin C1, slow skeletal and cardiac type. | 0.808 |
Mybpc3 | Tnni1 | ENSRNOP00000016652 | ENSRNOP00000067933 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.744 |
Mybpc3 | Tnni3 | ENSRNOP00000016652 | ENSRNOP00000024640 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.942 |
Mybpc3 | Tnnt2 | ENSRNOP00000016652 | ENSRNOP00000069434 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.940 |