node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adamtsl2 | Fbn1 | ENSRNOP00000030753 | ENSRNOP00000052876 | ADAMTS-like 2. | Fibrillin 1, isoform CRA_a. | 0.756 |
Adamtsl2 | Ltbp1 | ENSRNOP00000030753 | ENSRNOP00000040099 | ADAMTS-like 2. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.783 |
Adamtsl2 | Ltbp3 | ENSRNOP00000030753 | ENSRNOP00000028262 | ADAMTS-like 2. | Latent-transforming growth factor beta-binding protein 3. | 0.413 |
Efemp2 | Fbn1 | ENSRNOP00000072344 | ENSRNOP00000052876 | EGF-containing fibulin extracellular matrix protein 2. | Fibrillin 1, isoform CRA_a. | 0.754 |
Efemp2 | Ltbp1 | ENSRNOP00000072344 | ENSRNOP00000040099 | EGF-containing fibulin extracellular matrix protein 2. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.661 |
Fbn1 | Adamtsl2 | ENSRNOP00000052876 | ENSRNOP00000030753 | Fibrillin 1, isoform CRA_a. | ADAMTS-like 2. | 0.756 |
Fbn1 | Efemp2 | ENSRNOP00000052876 | ENSRNOP00000072344 | Fibrillin 1, isoform CRA_a. | EGF-containing fibulin extracellular matrix protein 2. | 0.754 |
Fbn1 | Itgav | ENSRNOP00000052876 | ENSRNOP00000069681 | Fibrillin 1, isoform CRA_a. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.605 |
Fbn1 | Itgb6 | ENSRNOP00000052876 | ENSRNOP00000074271 | Fibrillin 1, isoform CRA_a. | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.652 |
Fbn1 | Ltbp1 | ENSRNOP00000052876 | ENSRNOP00000040099 | Fibrillin 1, isoform CRA_a. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.971 |
Fbn1 | Ltbp2 | ENSRNOP00000052876 | ENSRNOP00000071831 | Fibrillin 1, isoform CRA_a. | Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly. Belongs to the LTBP family. | 0.597 |
Fbn1 | Ltbp3 | ENSRNOP00000052876 | ENSRNOP00000028262 | Fibrillin 1, isoform CRA_a. | Latent-transforming growth factor beta-binding protein 3. | 0.601 |
Fbn1 | Tgfb1 | ENSRNOP00000052876 | ENSRNOP00000028051 | Fibrillin 1, isoform CRA_a. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.793 |
Fbn1 | Tgfb2 | ENSRNOP00000052876 | ENSRNOP00000003313 | Fibrillin 1, isoform CRA_a. | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] | 0.728 |
Fbn1 | Tgfb3 | ENSRNOP00000052876 | ENSRNOP00000013516 | Fibrillin 1, isoform CRA_a. | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] | 0.584 |
Itgav | Fbn1 | ENSRNOP00000069681 | ENSRNOP00000052876 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Fibrillin 1, isoform CRA_a. | 0.605 |
Itgav | Itgb6 | ENSRNOP00000069681 | ENSRNOP00000074271 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.995 |
Itgav | Ltbp1 | ENSRNOP00000069681 | ENSRNOP00000040099 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity); Belongs to the LTBP family. | 0.756 |
Itgav | Ltbp3 | ENSRNOP00000069681 | ENSRNOP00000028262 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Latent-transforming growth factor beta-binding protein 3. | 0.571 |
Itgav | Tgfb1 | ENSRNOP00000069681 | ENSRNOP00000028051 | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.983 |