STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Adamts20ADAM metallopeptidase with thrombospondin type 1 motif, 20. (1909 aa)    
Predicted Functional Partners:
Tbx22
Similar to T-box 22 isoform 1.
      
 0.626
B3glct
Beta 3-glucosyltransferase.
    
 0.605
Pofut2
Protein O-fucosyltransferase 2 (Predicted), isoform CRA_a.
     
 0.558
LOC100910087
Disintegrin and metalloproteinase domain-containing protein 21-like.
   
  
 0.476
LOC100910087-2
Disintegrin and metalloproteinase domain-containing protein 21-like.
   
  
 0.476
Acan
Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
   
  
 0.458
Dennd6b
DENN domain-containing 6B.
      
 0.450
Msantd1
Myb/SANT DNA-binding domain-containing 1.
      
 0.421
Comp
Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...]
    
 
 0.414
Ssbp2
Single-stranded DNA-binding protein 2.
      
 0.411
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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