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Man2c1 protein (Rattus norvegicus) - STRING interaction network
"Man2c1" - Alpha-mannosidase 2C1 in Rattus norvegicus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Man2c1Alpha-mannosidase 2C1; Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity) (1039 aa)    
Predicted Functional Partners:
Man2b1
Alpha-mannosidase; Mannosidase, alpha, class 2B, member 1 (1009 aa)
     
 
  0.964
Man2b2
Alpha-mannosidase; Mannosidase, alpha, class 2B, member 2 (981 aa)
     
 
0.865
Fnbp1l
Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similari [...] (602 aa)
     
   
  0.792
Engase
Similar to RIKEN cDNA D230014K01 (Predicted); endo-beta-N-acetylglucosaminidase (732 aa)
   
   
  0.755
Man2a2
Alpha-mannosidase; Mannosidase, alpha, class 2A, member 2 (1161 aa)
           
  0.722
Manba
Beta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides (823 aa)
 
 
  0.718
Ngly1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native prote [...] (603 aa)
     
   
  0.717
Hook2
Hook microtubule-tethering protein 2 (719 aa)
     
   
  0.679
Gmds
GDP-mannose 4, 6-dehydratase (372 aa)
           
  0.676
Gcs1
Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family (834 aa)
     
   
  0.668
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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