node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl6ip1 | Atl1 | ENSRNOP00000024648 | ENSRNOP00000041993 | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.787 |
Arl6ip1 | Reep1 | ENSRNOP00000024648 | ENSRNOP00000061062 | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | Receptor expression-enhancing protein. | 0.519 |
Arl6ip1 | Reep2 | ENSRNOP00000024648 | ENSRNOP00000065717 | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | Receptor expression-enhancing protein. | 0.627 |
Arl6ip1 | Rtn2 | ENSRNOP00000024648 | ENSRNOP00000022528 | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | Reticulon. | 0.621 |
Arl6ip1 | Spast | ENSRNOP00000024648 | ENSRNOP00000033763 | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.488 |
Arl6ip1 | Zfyve27 | ENSRNOP00000024648 | ENSRNOP00000051399 | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.421 |
Atl1 | Arl6ip1 | ENSRNOP00000041993 | ENSRNOP00000024648 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | ADP-ribosylation factor-like GTPase 6-interacting protein 1. | 0.787 |
Atl1 | Nipa1 | ENSRNOP00000041993 | ENSRNOP00000061757 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human). | 0.844 |
Atl1 | Reep1 | ENSRNOP00000041993 | ENSRNOP00000061062 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein. | 0.969 |
Atl1 | Reep2 | ENSRNOP00000041993 | ENSRNOP00000065717 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Receptor expression-enhancing protein. | 0.831 |
Atl1 | Rtn2 | ENSRNOP00000041993 | ENSRNOP00000022528 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Reticulon. | 0.836 |
Atl1 | Rtn3 | ENSRNOP00000041993 | ENSRNOP00000028785 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Reticulon-3; May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (By similarity). | 0.787 |
Atl1 | Spart | ENSRNOP00000041993 | ENSRNOP00000054787 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Spartin. | 0.844 |
Atl1 | Spast | ENSRNOP00000041993 | ENSRNOP00000033763 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.948 |
Atl1 | Spg11 | ENSRNOP00000041993 | ENSRNOP00000071131 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | SPG11 vesicle-trafficking-associated, spatacsin. | 0.713 |
Atl1 | Zfyve27 | ENSRNOP00000041993 | ENSRNOP00000051399 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.751 |
Nipa1 | Atl1 | ENSRNOP00000061757 | ENSRNOP00000041993 | Non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human). | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. | 0.844 |
Nipa1 | Reep1 | ENSRNOP00000061757 | ENSRNOP00000061062 | Non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human). | Receptor expression-enhancing protein. | 0.771 |
Nipa1 | Reep2 | ENSRNOP00000061757 | ENSRNOP00000065717 | Non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human). | Receptor expression-enhancing protein. | 0.509 |
Nipa1 | Rtn2 | ENSRNOP00000061757 | ENSRNOP00000022528 | Non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human). | Reticulon. | 0.486 |